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题名: Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities
作者: Zhu, XF; Zhang, HX; Lo, R
刊名: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期: 2004
卷号: 52, 期号:24, 页码:7272-7278
关键词: artichoke ; Cynara scolymus L. ; antimicrobial activity ; phenolic compounds ; caffeoylquinic acid derivatives ; flavonoids
DOI: 10.1021/jf0490192
部门归属: 中国科学院环境生物技术重点实验室
英文摘要: A preliminary antimicrobial disk assay of chloroform, ethyl acetate, and n-butanol extracts of artichoke (Cynara scolymus L.) leaf extracts showed that the n-butanol fraction exhibited the most significant antimicrobial activities against seven bacteria species, four yeasts, and four molds. Eight phenolic compounds were isolated from the n-butanol soluble fraction of artichoke leaf extracts. On the basis of high-performance liquid chromatography/electrospray ionization mass spectrometry, tandem mass spectrometry, and nuclear magnetic resonance techniques, the structures of the isolated compounds were determined as the four caffeoylquinic acid derivatives, chlorogenic acid (1), cynarin (2), 3,5-di-O-caffeoylquinic acid (3), and 4,5-di-acaffeoylquinic acid (4), and the four flavonoids, luteolin-7-rutinoside (5), cynaroside (6), apigenin-7-rutinoside (7), and apigenin-7-O-beta-D-glucopyranoside (8), respectively. The isolated compounds were examined for their antimicrobial activities on the above microorganisms, indicating that all eight phenolic compounds showed activity against most of the tested organisms. Among them, chlorogenic acid, cynarin, luteolin-7-rutinoside, and cynaroside exhibited a relatively higher activity than other compounds; in addition, they were more effective against fungi than bacteria. The minimum inhibitory concentrations of these compounds were between 50 and 200 mug/mL.
研究领域[WOS]: Agriculture ; Chemistry ; Food Science & Technology
WOS记录号: WOS:000225358900013
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/23592
Appears in Collections:中国科学院环境生物技术重点实验室_期刊论文

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