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海洋天然产物Leiodelide A的全合成研究
张幸; 刘军; 杜宇国
Conference Name中国化学会第28届学术年会
Conference Date2012-04-13
Conference Place中国四川成都
AbstractLeiodelide A(1)是2006年美国Fenical小组从Leiodermatium海绵中分离得到的一种具有复杂结构的大环内酯化合物[1]。生物活性测试显示其对HL-60,NCI-H522,OVCAR-3等癌细胞的GI50值达到了0.25μM。由于LeiodelideA(1)分子结构复杂,而且C-13位甲基手性尚未确定,使其全合成富有挑战性,因此吸引了世界上多个研究组的关注[2]。我们以L-阿拉伯醇和D-乳酸为手性源,采用
Keyword海洋天然产物 Leiodelide a 手性源 全合成
Document Type会议论文
Recommended Citation
GB/T 7714
张幸,刘军,杜宇国. 海洋天然产物Leiodelide A的全合成研究[C],2012.
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