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天然产物Orthodiffenes A-C类化合物的全合成研究
刘军; 张幸; 刘义; 杜宇国
Conference Name中国化学会第28届学术年会
Conference Date2012-04-13
Conference Place中国四川成都
Abstract2011年初印度的Das研究小组从一种名为Orthosiphon diffusus的唇形科草本植物中分离出四种具有良好抗肿瘤活性的内酯类化合物,分别命名为Orthodiffenes A-C(1-3)。初步生物活性测试表明:该类化合物对HL-60与Jurkat等癌细胞表现出显著的抑制活性,特别是化合物Orthodiffene B表现出了与喜树碱相当的生物活性(IC50=1.76μg/mL)。截止到目前,没有任何关于Orthodiffenes类化合物的全
Keyword天然产物 Orthodiffenes 手性源 全合成
Document Type会议论文
Recommended Citation
GB/T 7714
刘军,张幸,刘义,等. 天然产物Orthodiffenes A-C类化合物的全合成研究[C],2012.
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