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题名: 2,3,7,8-Tetrachlorodibenzo-p-dioxin suppress AChE activity in NGF treated PC12 cells
作者: Xu, Li; Chen, Yangsheng; Xie, Heidi Q. H.; Xu, Tuan; Fu, Hualing; Zhang, Songyan; Tsim, Karl W. K.; Bi, Cathy W. C.; Zhao, Bin
刊名: CHEMICO-BIOLOGICAL INTERACTIONS
出版日期: 2016-11-25
卷号: 259, 期号:0, 页码:282-285
关键词: AChE ; Acetylcholinesterase ; Dioxin ; 2,3,7,8-TCDD ; PC12 ; Neuronal differentiation ; NGF ; Nerve growth factor
DOI: 10.1016/j.cbi.2016.08.003
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: PC12 is a well studied cell model for neuronal differentiation. AChE is also considered as a marker for neuronal differentiation. In this study, we detected the change of AChE activity during the NGF induced differentiation of PC 12 cells, and targeted on the ratio of the activity of AChE on the cell surface, and found that NGF mainly increased the intracellular AChE activity. Dioxin is a kind of persistent organic pollutants which have extreme impact on human health and widely distributed all over the world. Recently, AChE was reported as a target of the toxicity of dioxin. Here we investigated the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on AChE activity in the PC12 cells, and found that at the later stage of differentiation, TCDD could decrease the AChE activity. This down regulation might not related to transcriptional regulation. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35790
Appears in Collections:环境化学与生态毒理学国家重点实验室_期刊论文

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