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题名: Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis
作者: Fan, Rui-mei; Zhu, Ben-zhan; Huang, Chin-pao; Sheng, Zhi-guo; Mao, Li; Li, Ming-xin
刊名: ENVIRONMENTAL TOXICOLOGY
出版日期: 2016-12
卷号: 31, 期号:12, 页码:1964-1973
关键词: metam ; copper (II) ; zinc (II) ; synergistic toxicity ; apoptosis ; necrosis
DOI: 10.1002/tox.22197
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: Both metam sodium and copper/zinc-containing compounds are widely used as fungicides. They therefore may co-occur in the biosphere. Despite certain studies of individual toxicity for either metam or copper (II)/zinc (II), their synergistic toxicity has not been examined. In this paper, a remarkable synergistic toxicity was observed in HepG2 cells when metam and copper (II)/zinc (II) at non-toxic and sub-toxic levels were combined. Unexpectedly, cell death modes between metam/copper (II) and metam/zinc (II) were different: For metam/copper (II), apoptosis was evident from morphological characteristics including cytoplasm-chromatin condensation, phosphatidylserine (PS) exposure, SubG(0)/G(1) DNA fragmentation, mitochondrial membrane potential decrease, pro/anti-apoptotic protein activation, and cytochrome c release; for metam/zinc (II), necrosis was evident from organelle swelling and uncontrolled collapse. To our knowledge, this work first not only demonstrates the synergistic toxicities of metam and both copper (II)/zinc (II), but also verifies the different modes of apoptosis/necrosis between metam/copper (II) and metam/zinc (II). (C) 2015 Wiley Periodicals, Inc.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35839
Appears in Collections:环境化学与生态毒理学国家重点实验室_期刊论文

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Recommended Citation:
Fan, Rui-mei,Zhu, Ben-zhan,Huang, Chin-pao,et al. Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis[J]. ENVIRONMENTAL TOXICOLOGY,2016,31(12):1964-1973.
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文件名: Different Modes of Synergistic Toxicities between MetamCopper (II) and MetamZinc (II) in HepG2 Cells Apoptosis vs. Necrosis.pdf
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