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题名: Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards (Eremias argus) Following Oral Administration
作者: Chen, Li; Xu, Peng; Diao, Jinling; Di, Shanshan; Li, Ruiting; Zhou, Zhiqiang
刊名: JOURNAL OF HAZARDOUS MATERIALS
出版日期: 2016-04-05
卷号: 306, 期号:0, 页码:87-94
关键词: Beta-cypermethrin ; Degradation ; Organ coefficient ; Histopathology
DOI: 10.1016/j.jhazmat.2015.11.053
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: Beta-cypermethrin (BCYP), a synthetic pyrethriod (PYR) pesticide which is a mixture of the alpha- and theta- cypermethrin, have been reported various toxicological profiles to non-target organisms. But little is known about assimilation, accumulation and toxic effects of BCYP in reptiles. The present study firstly elucidated absorption, tissue distribution, excretion of BCYP in Eremias argus. Treated group were administered orally with BCYP 20 mg/kg body weight (bw) dissolved in corn oil. Neurotoxicity was observed at 24 h after gavage, and the poisoning symptom ameliorated at 72 h. The changes of BCYP concentration depended on degradation time and tissues. Lizards had a strong capacity to eliminate BCYP with different tissue distribution. The tissues concentration of BCYP from high to low were intestine, stomach, heart, kidney, blood, lung, liver and brain. Bimodal phenomena were observed in lung, liver and kidney. These results may be due to the activities of enzymes, circadian rhythm, and enterohepatic circulation in lizards. Based on the results of organ coefficient and histopathology analysis in liver, the liver was confirmed as the main target organ. (C) 2015 Elsevier B.V. All rights reserved.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35843
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