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Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards (Eremias argus) Following Oral Administration
Chen, Li; Xu, Peng; Diao, Jinling; Di, Shanshan; Li, Ruiting; Zhou, Zhiqiang
2016-04-05
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
Volume306Issue:0Pages:87-94
AbstractBeta-cypermethrin (BCYP), a synthetic pyrethriod (PYR) pesticide which is a mixture of the alpha- and theta- cypermethrin, have been reported various toxicological profiles to non-target organisms. But little is known about assimilation, accumulation and toxic effects of BCYP in reptiles. The present study firstly elucidated absorption, tissue distribution, excretion of BCYP in Eremias argus. Treated group were administered orally with BCYP 20 mg/kg body weight (bw) dissolved in corn oil. Neurotoxicity was observed at 24 h after gavage, and the poisoning symptom ameliorated at 72 h. The changes of BCYP concentration depended on degradation time and tissues. Lizards had a strong capacity to eliminate BCYP with different tissue distribution. The tissues concentration of BCYP from high to low were intestine, stomach, heart, kidney, blood, lung, liver and brain. Bimodal phenomena were observed in lung, liver and kidney. These results may be due to the activities of enzymes, circadian rhythm, and enterohepatic circulation in lizards. Based on the results of organ coefficient and histopathology analysis in liver, the liver was confirmed as the main target organ. (C) 2015 Elsevier B.V. All rights reserved.
Department环境化学与生态毒理学国家重点实验室
KeywordBeta-cypermethrin Degradation Organ Coefficient Histopathology
DOI10.1016/j.jhazmat.2015.11.053
Indexed BySCI
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Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/35843
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Chen, Li,Xu, Peng,Diao, Jinling,et al. Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards (Eremias argus) Following Oral Administration[J]. JOURNAL OF HAZARDOUS MATERIALS,2016,306(0):87-94.
APA Chen, Li,Xu, Peng,Diao, Jinling,Di, Shanshan,Li, Ruiting,&Zhou, Zhiqiang.(2016).Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards (Eremias argus) Following Oral Administration.JOURNAL OF HAZARDOUS MATERIALS,306(0),87-94.
MLA Chen, Li,et al."Distribution, Metabolism and Toxic Effects of Beta-Cypermethrin in Lizards (Eremias argus) Following Oral Administration".JOURNAL OF HAZARDOUS MATERIALS 306.0(2016):87-94.
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