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题名: Functionalized single-walled carbon nanotubes for the improved solubilization and delivery of curcumin
作者: Yuan, Shaopeng; Zeng, Luzhe; Zhuang, Yuanyuan; Hou, Qi; Song, Maoyong
刊名: FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
出版日期: 2016-01
卷号: 24, 期号:1, 页码:13-19
关键词: single-walled carbon nanotubes ; functionalization ; curcumin ; drug delivery
DOI: 10.1080/1536383X.2015.1088007
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: The surface modification of single-walled carbon nanotubes (SWCNTs) can enhance their solubility and stability in water and biological systems. The present study demonstrated the application of the functionalized SWCNTs (f-SWCNTs) as drug-delivery vehicles. In this study, f-SWCNTs were functionalized with one of four different chemical groups for the delivery of curcumin to splenic lymphocytes. Since free curcumin can modulate the proliferation of splenic lymphocytes, we compared the abilities of different f-SWCNTs for the delivery of water-insoluble curcumin to inhibit cell proliferation, which were stimulated with concanavalin A (Con A) and lipopolysaccharide (LPS). The results showed that curcumin can be loaded onto the f-SWCNTs surface through pi-pi stacking with a loading capacity of 235-327 mg/g (curcumin/f-SWCNTs). The f-SWCNTs-curcumin complexes display considerable cell proliferation inhibition efficacy when compared with free curcumin diluted in dimethyl sulfoxide (DMSO). Furthermore, curcumin loaded onto SWCNTs functionalized with poly(ethylene glycol) (SW-PEG) showed good dispersion and stability in water, confirming the excellent biocompatibility of SW-PEG as a drug carrier.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35860
Appears in Collections:环境化学与生态毒理学国家重点实验室_期刊论文

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