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题名: Genotoxicity of quinolone antibiotics in chlorination disinfection treatment: formation and QSAR simulation
作者: Li, Min; Wei, Dongbin; Du, Yuguo
刊名: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
出版日期: 2016-10
卷号: 23, 期号:20, 页码:20637-20645
关键词: Quinolone ; Chlorination ; Disinfection ; Genotoxicity ; QSAR ; CoMSIA
DOI: 10.1007/s11356-016-7246-4
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: Lots of unexpected disinfection by-products were formed during the chlorination disinfection of contaminated water bodies, leading to a potential threat to human health and ecological safety. In this study, SOS/umu assay was used to trace the genotoxicity variation of 20 quinolone compounds during the chlorination disinfection. Furthermore, two- and three-dimensional quantitative structure-activity relationship models were developed based on the electronic and hydrophobic properties of the quinolones, which were used to quantify the impact of the different structural features of the compounds on their genotoxicity variation. The results revealed that quinolones bearing hydrophilic substituents with less H-bond donors and negative charge at the 1-position of the quinolone ring exhibited a positive correlation with genotoxicity elevation. More notably, the chlorination of quinolones in both ultrapure water and secondary effluent matrices provided comparable levels of genotoxicity, indicating that our research could potentially be used to evaluate the environmental risk of quinolone antibiotics in chlorination disinfection treatment.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35862
Appears in Collections:环境化学与生态毒理学国家重点实验室_期刊论文

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Recommended Citation:
Li, Min,Wei, Dongbin,Du, Yuguo. Genotoxicity of quinolone antibiotics in chlorination disinfection treatment: formation and QSAR simulation[J]. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2016,23(20):20637-20645.
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文件名: Genotoxicity of quinolone antibiotics in chlorination disinfection treatment formation and QSAR simulation.pdf
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