中国科学院生态环境研究中心机构知识库
Advanced  
RCEES OpenIR  > 环境化学与生态毒理学国家重点实验室  > 期刊论文
题名: Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
作者: Zhang, Yi; Wang, Yabin; Liu, Aijuan; Xu, Sherry Li; Zhao, Bin; Zhang, Yi; Zou, Hanfa; Wang, Wenyi; Zhu, Hao; Yan, Bing
刊名: ADVANCED FUNCTIONAL MATERIALS
出版日期: 2016-02-09
卷号: 26, 期号:6, 页码:841-850
关键词: combinatorial chemistry ; CYP450 ; functionalized MWCNTs ; human liver microsome ; pharmacophores
DOI: 10.1002/adfm.201504182
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: The liver plays an important role in metabolizing foreign materials, such as drugs. The high accumulation of carbon nanotubes and other hydrophobic nanoparticles in the liver has raised concerns that nanoparticles may interfere with liver metabolic function. We report here that carbon nanotubes enter hepatic cells after intravenous introduction and interact with CYP enzymes, including CYP3A4. Surface chemical modifications alter the carbon nanotubes' interactions with CYP450 enzymes in human liver microsomes. They enhance, inhibit, or have no effect on the enzymatic function of CYP3A4. Using a cheminformatics analysis, certain chemical structures are identified on the surface of the carbon nanotubes that induce an enzyme inhibitory effect or prevent disruption of CYP3A4 enzymes.
收录类别: SCI
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35897
Appears in Collections:环境化学与生态毒理学国家重点实验室_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver.pdf(2191KB)期刊论文作者接受稿开放获取View 联系获取全文
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Yi]'s Articles
[Wang, Yabin]'s Articles
[Liu, Aijuan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Yi]‘s Articles
[Wang, Yabin]‘s Articles
[Liu, Aijuan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院生态环境研究中心 - Feedback
Powered by CSpace