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题名: Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China
作者: Fu, Jianjie; Gao, Yan; Cui, Lin; Wang, Thanh; Liang, Yong; Qu, Guangbo; Yuan, Bo; Wang, Yawei; Zhang, Aiqian; Jiang, Guibin
刊名: SCIENTIFIC REPORTS
出版日期: 2016-12-01
卷号: 6, 期号:0, 页码:-
DOI: 10.1038/srep38039
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: Paired serum and urine samples were collected from workers in a fluorochemical plant from 2008 to 2012 (n = 302) to investigate the level, temporal trends, and half-lives of PFAAs in workers of a fluorochemical plant. High levels of perfluorohexane sulfonate (PFHxS), perfluorooctanoic acid (PFOA), and perfluorooctanesulfonate (PFOS) were detected in serum with median concentrations of 764, 427, and 1725 ng mL(-1), respectively. The half-lives of PFAAs in workers were estimated by daily clearance rates and annual decline rates of PFAAs in serum by a first-order model. The geometric mean and median value for PFHxS, PFOA, and PFOS were 14.7 and 11.7, 4.1 and 4.0, 32.6 and 21.6 years, respectively, by the daily clearance rates, and they were 3.6, 1.7, and 1.9 years estimated by annual decline rates. The half-lives estimated by the limited clearance route information could be considered as the upper limits for PFAAs, however, the huge difference between two estimated approaches indicated that there were other important elimination pathways of PFAAs other than renal clearance in human. The half-lives estimated by annual decline rates in the present study were the shortest values ever reported, and the intrinsic half-lives might even shorter due to the high levels of ongoing exposure to PFAAs.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35914
Appears in Collections:环境化学与生态毒理学国家重点实验室_期刊论文

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