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题名: Silver nanoparticles induced neurotoxicity through oxidative stress in rat cerebral astrocytes is distinct from the effects of silver ions
作者: Sun, Cheng; Yin, Nuoya; Wen, Ruoxi; Liu, Wei; Jia, Yanxia; Hu, Ligang; Zhou, Qunfang; Jiang, Guibin
刊名: NEUROTOXICOLOGY
出版日期: 2016-01
卷号: 52, 期号:0, 页码:210-221
关键词: Silver nanoparticle ; Silver ion release ; Particle effect ; Neurotoxicity ; Astrocyte
DOI: 10.1016/j.neuro.2015.09.007
部门归属: 环境化学与生态毒理学国家重点实验室
英文摘要: The rapid development of silver nanoparticles (AgNPs) based products has raised increasing concerns in view of their potential hazardous risks to the environment and human health. The roles of the released silver ions in AgNPs induced cytotoxicities are being hotly debated. Using rat cerebral astrocytes, the neurotoxicological effects of AgNPs and silver ions were investigated. Acute toxicity based on Alamar Blue assay showed that silver ions were considerably more toxic than AgNPs. Comparative studies indicated that AgNPs increased caspase activities and induced cell apoptosis under cytotoxic level of exposures, while silver ions compromised cell membrane integrity and dominantly caused cell necrosis. Cellular internalization of silver provided the basis for the cytotoxicities of these two silver species. In contrast to silver ions, intracellular reactive oxygen species (ROS) generation occurred in time- and concentration-dependent manners in astrocytes upon AgNPs stimulation, which caused subsequent c-Jun N-terminal kinases UNK) phosphorylation and promoted the programmed cell death. Non-cytotoxic level of AgNPs exposure increased multiple cytokines secretion from the astrocytes, indicating that AgNPs were potentially involved in neuroinflammation. This effect was independent of silver ions as well. The distinct toxicological effects caused by AgNPs and silver ions provided the solid proofs for the particle-specific effects which should be concerned regarding the accurate assessment of AgNPs exposure risks. (C) 2015 Elsevier Inc. All rights reserved.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/35942
Appears in Collections:环境化学与生态毒理学国家重点实验室_期刊论文

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