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题名: Evaluation and characterization of thyroid-disrupting activities in soil samples along the Second Songhua River, China
作者: Kong, Dongdong; Wang, Yafei; Wang, Jinsheng; Teng, Yanguo; Li, Na; Li, Jian
刊名: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
出版日期: 2016-11
卷号: 133, 期号:0, 页码:475-480
关键词: In vitro bioassay ; Thyroid receptor ; Soil sample ; Thyroid-disrupting chemicals
DOI: 10.1016/j.ecoenv.2016.08.005
部门归属: 环境水质学国家重点实验室
英文摘要: In this study, a recombinant thyroid receptor (TR) gene yeast assay combined with Monte Carlo simulation were used to evaluate and characterize soil samples collected from Jilin (China) along the Second Songhua River, for their ant/agonist effect on TR. No TR agonistic activity was found in soils, but many soil samples exhibited TR antagonistic activities, and the bioassay-derived amiodarone hydrochloride equivalents, which was calculated based on Monte Carlo simulation, ranged from not detected (N.D.) to 35.5 mu g/g. Hydrophilic substance fractions were determined to be the contributors to TR antagonistic activity in these soil samples. Our results indicate that the novel calculation method is effective for the quantification and characterization of TR antagonists in soil samples, and these data could provide useful information for future management and remediation efforts for contaminated soils. (C) 2016 Elsevier Inc. All rights reserved.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/36040
Appears in Collections:环境水质学国家重点实验室_期刊论文

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