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题名: Chlorination by-products of bisphenol A enhanced retinoid X receptor disrupting effects
作者: Li, Na; Jiang, Weiwei; Ma, Mei; Wang, Donghong; Wang, Zijian
刊名: JOURNAL OF HAZARDOUS MATERIALS
出版日期: 2016-12-15
卷号: 320, 期号:0, 页码:289-295
关键词: Retinoid X receptor ; Bisphenol A ; Chlorinated byproducts ; TEQ ; Molecular docking
DOI: 10.1016/j.jhazmat.2016.08.033
部门归属: 中国科学院饮用水科学与技术重点实验室
英文摘要: There is increasing evidence of activities of chlorinated by-products of bisphenol A (BPA) on retinoic acid system. Their agonistic and antagonistic activities to human retinoid X receptor (RXR) were assessed by a two-hybrid yeast assay. Aqueous solutions of 1 mg/L BPA were chlorinated by sodium hypochlorite (NaClO). It showed that chlorination of BPA increased RXR beta antagonistic activity, while no agonistic activity was detected, showing chlorine might act as a toxic potentiator rather than a toxic deactivator in RXR beta disrupting effects. BPA and its byproducts including 2,2',6,6'-tetrachlorobisphenol A (TCBPA) and 2,4,6-trichlorophenol (TCP) were quantitatively determined by gas chromatography/mass spectrometry (GC/MS). BPA rapidly degraded. With the increasing of ICC and reaction time, concentration of formed TCBPA increased initially then decreased, while concentration of formed TCP increased stably. Using the toxic equivalent (TEQ) approach, the, main contributors should be mono-, di- and tri- chlorobisphenol A at initial chlorine concentration (ICC) of 1 mg/L. At ICC of 2 and 5 mg/L, the main contributors were TCBPA and TCP, being 57.7%-70.7% and 45.3%-59.4%. Molecular docking showed BPA chlorination by-products might have the same mode of action with BPA, forming hydrogen bond and pi-pi interaction with their OH group or hydrophobic ring. (C) 2016 Elsevier B.V. All rights reserved.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/36161
Appears in Collections:中国科学院饮用水科学与技术重点实验室_期刊论文

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