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题名: Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus)
作者: Yuan, Lilai; Li, Jiasu; Zha, Jinmiao; Wang, Zijian
刊名: ENVIRONMENTAL POLLUTION
出版日期: 2016-01
卷号: 208, 期号:0, 页码:670-677
关键词: Organophosphate flame retardants ; Neurological effects ; Cholinesterase and neurotransmitter systems ; Neurotrophic factors ; Chinese rare minnow
DOI: 10.1016/j.envpol.2015.10.045
部门归属: 中国科学院饮用水科学与技术重点实验室
英文摘要: Organophosphate flame retardants (OPFRs) have been detected at high concentrations in various environmental and biotic samples, but little is known about their toxicity. In this study, the potential neurotoxicity of three OPERs (TCEP, TDCPP, and TPP) and Chlorpyrifos (CPF, an organophosphate pesticide) were compared in Chinese rare minnow using an acute toxicity test and a 21-day fish assay. The acute test demonstrated significant inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) by CPF. Although significant AChE inhibition at high concentration of TPP was also observed, none of the OPERs had effects similar to CPF on these enzymes, indicating that their acute toxicities to Chinese rare minnow may be unrelated to cholinesterase inhibition. In addition, the 21-day fish assay with TDCPP demonstrated no significant effects on cholinesterase activities or neurotransmitter levels. Nonetheless, this OPFR exhibited widespread effects on the neurotrophic factors and their receptors (e.g., ntf3, ntrk1, ntrk2, ngfr, and fgf2, fgf11, fgf22, fgfr4), indicating that TDCPP or other OPFRs may elicit neurological effects by targeting neurotrophic factors and their receptors in Chinese rare minnow. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别: SCI
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内容类型: 期刊论文
URI标识: http://ir.rcees.ac.cn/handle/311016/36217
Appears in Collections:中国科学院饮用水科学与技术重点实验室_期刊论文

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