A high throughout screening method was applied to screening the organic pollutants in 47 sediments from the Daqinghe River Watershed. A total of 104 organic contaminants were identified,of which 54 were detected at more than 10% sites. The developed risk-based screening procedure was used for priority setting of the 54 contaminants and the probability of risk was calculated. The results showed that 11 contaminants were selected as priorities in the Daqinghe River Watershed. These were pesticides,industry chemicals,and home and personal care products. This study has proved that the developed risk-based screening procedure has the ability of identifying and ranking the priority pollutants in the environment at the watershed scale.