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Interindividual variability of soil arsenic metabolism by human gut microbiota using SHIME model
Yin, Naiyi; Du, Huili; Wang, Pengfei; Cai, Xiaolin; Chen, Peng; Sun, Guoxin; Cui, Yanshan
2017-10-01
Source PublicationCHEMOSPHERE
Volume184Issue:0Pages:460-466
AbstractArsenic (As) metabolism by human gut microbiota has been evidenced with in vitro experiments from contaminated soils. In this study, the variability in the metabolic potency toward As-contaminated soils and gut microbial diversity were investigated between healthy individuals (Adult versus Child). Arsenic bioaccessibility in the colon phase increased by 1.4-6.8 and 1.2-8.7 folds for adult and child, respectively. We found a high degree of As methylation for the colon digests of the adult (mean 2 mu g methylarsenicals/hr/g biomass), 3-folds higher than that of the child. Besides, arsenite [As(III)] concentration (1.5-391.3 mu g/L) for the child was 2-18 times for the adult. 16S rRNA gene sequencing revealed that human gut microbiota from 20 various genera potentially had resistance genes to reduce and methylate As under conservative statistics. Our results indicated that As metabolism by gut microbiota from adult and child was significantly different. The adult gut microbiota had a great ability of As methylation; the child gut microbiota exhibited high As(III) level, which could encounter high health risk. The identity and activity of arsenic-metabolizing bacteria isolated from human gut and its homologous role in As metabolism need be further explored. This study provides a better understanding of health risk assessment to adults and children upon soil As exposures. (C) 2017 Elsevier Ltd. All rights reserved.
Department土壤环境科学实验室
KeywordArsenic Species Metabolism Human Health Soil
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/39591
Collection土壤环境科学实验室
Recommended Citation
GB/T 7714
Yin, Naiyi,Du, Huili,Wang, Pengfei,et al. Interindividual variability of soil arsenic metabolism by human gut microbiota using SHIME model[J]. CHEMOSPHERE,2017,184(0):460-466.
APA Yin, Naiyi.,Du, Huili.,Wang, Pengfei.,Cai, Xiaolin.,Chen, Peng.,...&Cui, Yanshan.(2017).Interindividual variability of soil arsenic metabolism by human gut microbiota using SHIME model.CHEMOSPHERE,184(0),460-466.
MLA Yin, Naiyi,et al."Interindividual variability of soil arsenic metabolism by human gut microbiota using SHIME model".CHEMOSPHERE 184.0(2017):460-466.
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