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Toxicological effects on earthworms (Eisenia fetida) exposed to sub-lethal concentrations of BDE-47 and BDE-209 from a metabolic point
Liang, Ruoyu; Chen, Juan; Shi, Yajuan; Lu, Yonglong; Sarvajayakesavalu, Suriyanarayanan; Xu, Xiangbo; Zheng, Xiaoqi; Khan, Kifayatullah; Su, Chao
2018-09-01
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume240Pages:653-660
AbstractEarthworms improve the soil fertility and they are also sensitive to soil contaminants. Earthworms (Eisenia fetida), standard reference species, were usually chosen to culture and handle for toxicity tests. Metabolic responses in earthworms exposed to 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) and decabromodiphenyl ether (BDE-209) were inhibitory and interfered with basal metabolism. In this study, H-1-NMR based metabolomics was used to identify sensitive biomarkers and explore metabolic responses of earthworms under sub-lethal BDE-47 and BDE-209 concentrations for 14 days. The results revealed that lactate was accumulated in earthworms exposed to BDE-47 and BDE-209. Glutamate increased significantly when the concentration of BDE-47 and BDE-209 reached 10 mg/kg. The BDE-47 exposure above 50 mg/kg concentration decreased the content of fumarate significantly, which was noticed different from that of BDE-209. Whereas, the BDE-207 or BDE-209 exposure increased the protein degradation into amino acids in vivo. The increased betaine content indicated that earthworms may maintain the cell osmotic pressure and protected enzyme activity by metabolic regulation. Moreover, the BDE-47 and BDE-209 exposure at 10 mg/kg changed most of the metabolites significantly, indicating that the metabolic responses were more sensitive than growth inhibition and gene expression. The metabolomics results revealed the toxic modes of BDE-47 and BDE-209 act on the osmoregulation, energy metabolism, nerve activities, tricarboxylic acid cycle and amino acids metabolism. Furthermore, our results highlighted that the H-1-NMR based metabolomics is a strong tool for identifying sensitive biomarkers and eco-toxicological assessment. (C) 2018 Elsevier Ltd. All rights reserved.
Department城市与区域生态国家重点实验室
KeywordBDE-47 BDE-209 Ecotoxicology Metabolomics POPs
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/40688
Collection城市与区域生态国家重点实验室
Recommended Citation
GB/T 7714
Liang, Ruoyu,Chen, Juan,Shi, Yajuan,et al. Toxicological effects on earthworms (Eisenia fetida) exposed to sub-lethal concentrations of BDE-47 and BDE-209 from a metabolic point[J]. ENVIRONMENTAL POLLUTION,2018,240:653-660.
APA Liang, Ruoyu.,Chen, Juan.,Shi, Yajuan.,Lu, Yonglong.,Sarvajayakesavalu, Suriyanarayanan.,...&Su, Chao.(2018).Toxicological effects on earthworms (Eisenia fetida) exposed to sub-lethal concentrations of BDE-47 and BDE-209 from a metabolic point.ENVIRONMENTAL POLLUTION,240,653-660.
MLA Liang, Ruoyu,et al."Toxicological effects on earthworms (Eisenia fetida) exposed to sub-lethal concentrations of BDE-47 and BDE-209 from a metabolic point".ENVIRONMENTAL POLLUTION 240(2018):653-660.
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