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Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells
Ji, Zhihua; Zhang, Yaxian; Tian, Juan; Wang, Fengbang; Song, Maoyong; Li, Hao
2018-10-15
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
Volume161Pages:1-7
AbstractTetrachlorobisphenol A (TCBPA), which is widely used as flame retardant, can be released into various environments, thereby being absorbed by wildlife or human beings through food chain's bio-magnification and causing some adverse influences on wildlife or human beings. However, limited data are currently available on TCBPA-associated cytotoxicity and related mechanisms. Here, the cytotoxicity induced by different concentrations of TCBPA (i.e., 5, 10 and 20 mu M) was studied using Saccharomyces cerevisiae, a simple eukaryotic model organism. TCBPA treatment inhibited the growth and survival rate of yeast cell in a dose-dependent manner. Moreover, TCBPA promoted the increasing of intracellular oxidative stress by enhancing accumulation of intracellular reactive oxygen species (ROS). Meanwhile, lipid peroxidation degree (represented by malondialdehyde (MDA) content) and DNA damage degree (represented by 8-hydroxy deoxyguanosine (8-oxodG) content) in yeast cell also increased after TCBPA treatment. However, yeast cell mitochondrial membrane potential (Delta psi m) decreased after TCBPA treatment. It was noteworthy that there was no significant inhibitory effect on yeast cell growth or survival rate in 5 mu M TCBPA-treated cells, but the intracellular MDA content and Delta psi m level changed significantly, suggesting the potential cell damage secondary to the relative low dose of TCBPA exposure. Results presented here would highlight our knowledge about TCBPA-associated cytotoxicity in organisms.
Department环境纳米技术与健康效应重点实验室
KeywordTetrachlorobisphenol A Cytotoxicity Saccharomyces cerevisiae Oxidative stress
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/41098
Collection环境纳米技术与健康效应重点实验室
Recommended Citation
GB/T 7714
Ji, Zhihua,Zhang, Yaxian,Tian, Juan,et al. Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2018,161:1-7.
APA Ji, Zhihua,Zhang, Yaxian,Tian, Juan,Wang, Fengbang,Song, Maoyong,&Li, Hao.(2018).Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,161,1-7.
MLA Ji, Zhihua,et al."Oxidative stress and cytotoxicity induced by tetrachlorobisphenol A in Saccharomyces cerevisiae cells".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 161(2018):1-7.
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