RCEES OpenIR  > 环境水质学国家重点实验室
Byproducts of aqueous chlorination of equol and their estrogenic potencies
Zhou, Yuyin; Zhang, Shiyi; Zhao, Fanrong; Zhang, Hong; An, Wei; Yang, Min; Zhang, Zhaobin; Hu, Jianying
2018-01-12
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume212Pages:393-399
SubtypeArticle
AbstractWhile the phytoestrogen metabolite equol has been reported to exist in surface water, its behavior in drinking water treatment plants remains unrevealed. In this study, eight products including four chlorinated equols (monochloro-equol, dichloro-equol, trichloro-equol, and tetrachloro-equol) were identified in an aqueous chlorinated equol solution by UHPLC-quadrupole-orbitrap-HRMS. Two main pathways of chlorination reaction are proposed: (1) chlorine-substitution reactions on the aromatic ring and subsequent dehydration to form the chlorine-substituted equols, and (2) break-up of the heterocyclic ring with oxygen followed by oxidation of aldehyde to carboxyl. The human estrogen receptor (hER) activating activity for monochloro-equol (EC50 = 3456 nM) and dichloro-equol (EC50 = 2456 nM) were slightly stronger than that of equol (EC50 = 3889 nM). This is the first report on the behavior of equol in drinking water chlorination, which provided an important information on the risk assessment of equol in drinking water. (C) 2018 Elsevier Ltd. All rights reserved.
Department环境水质学国家重点实验室
KeywordBy-product Chlorination Chlorinated equols Estrogenic activity Drinking water
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/41112
Collection环境水质学国家重点实验室
Recommended Citation
GB/T 7714
Zhou, Yuyin,Zhang, Shiyi,Zhao, Fanrong,et al. Byproducts of aqueous chlorination of equol and their estrogenic potencies[J]. CHEMOSPHERE,2018,212:393-399.
APA Zhou, Yuyin.,Zhang, Shiyi.,Zhao, Fanrong.,Zhang, Hong.,An, Wei.,...&Hu, Jianying.(2018).Byproducts of aqueous chlorination of equol and their estrogenic potencies.CHEMOSPHERE,212,393-399.
MLA Zhou, Yuyin,et al."Byproducts of aqueous chlorination of equol and their estrogenic potencies".CHEMOSPHERE 212(2018):393-399.
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