大气细颗粒物对血浆关键蛋白酶系相互作用 和血小板生成的影响及机理研究 | |
晋小婷 | |
Subtype | 博士后 |
Thesis Advisor | 江桂斌 ; 周群芳 |
2019-12 | |
Degree Grantor | 中国科学院生态环境研究中心 |
Place of Conferral | 北京 |
Degree Name | 理学 |
Degree Discipline | 环境科学 |
Keyword | 大气细颗粒物 血液效应 血浆蛋白酶系 巨核细胞 血小板 airborne Fine Particles, Hematological Effect, Plasma Protease System, Megakaryocyte, Platelet |
Abstract | 因人类活动产生的大气细颗粒物污染及由此引起的人体健康风险,已成为全球关注的重要议题。大气 细 颗粒物 成分复杂 、理化性质独特 ,现有毒理学数据大多局限于这类污染物的靶器官毒性效应, 不能充分解释 其 暴露与健康危害间的因果关系, 其 毒性模式与作用机制仍需进一步 研究 。 考虑到污染物在进入机体到达靶器官前大多会进入血液循环系统,而血浆体系中富含多种重要酶系,这些酶系相互作用共同调节血液稳态及心血管系统中诸多生物学过程,因此大气细颗粒物与血浆酶系可能存在的相互作用值得探索。此外,血小板是由巨核细胞胞浆脱落下来的小块胞质,在血液中广泛存在,在生理止血过程中发挥着重要的功能。肺脏是大气细颗粒物暴露的重要靶器官,同时也被报道是体内血小板生成的重要器官之一。大气细颗粒物暴露是否可能影响机体血小板的生成,这对客观评价这类污染物引发心血管疾病风险具有重要意义。本研究分别选用无机石英滤膜(QFF)和有机聚丙烯滤膜(PPF),采集了北京市冬季大气细颗粒物 PM1和 PM2.5样本 。 |
Other Abstract | Particulate air pollution from human activities has drawn global attention due to its potential health risks. Due to various physical and chemical properties of airborne fine particulate matter (PM), the currently available toxicological data on PM is still not sufficient to explain their cause-and-effect. Considering the inevitable contact of inhaled airborne PM with the plasma, the hematological effects of PM are worthy of being studied. The complement, coagulation and kallikrein-kinin system (KKS), key zymogens in plasma, are working in concert with each other to provide both positive and negative feedback for hematological hemostasis. In addition, platelet, derived from the differentiation of megakaryocyte and widely found in blood, can regulate various physiological and pathological processes. Lung tissue belongs to the important target of PM and a primary site of platelet production. Hence, the effects of airborne fine particles on key zymogens and platelet formation may be an important prerequisite for determining their health risks. Herein, airborne PM samples were collected by inorganic quartz fiber filters (QFFs) and organic polypropylene filters (PPFs) in Beijing during winter. Based on the physicochemical characterization of these particle samples, their potential effectss on plasma zymogens and platelet generation were investigated. |
Pages | 103 |
Language | 中文 |
Document Type | 学位论文 |
Identifier | http://ir.rcees.ac.cn/handle/311016/42223 |
Collection | 环境化学与生态毒理学国家重点实验室 |
Recommended Citation GB/T 7714 | 晋小婷. 大气细颗粒物对血浆关键蛋白酶系相互作用 和血小板生成的影响及机理研究[D]. 北京. 中国科学院生态环境研究中心,2019. |
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