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High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples
Liu, Yanna1; D'Agostino, Lisa A.; Qu, Guangbo3,4; Jiang, Guibin3,4; Martin, Jonathan W.
2019-12-01
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume121Pages:-
AbstractWidespread environmental contamination of legacy long-chain poly- and per-fluoroalkyl substances (PFASs) has triggered chemical regulatory action and a global transitioning to alternative PFASs. More than 5000 PFASs are now recognized on various lists, but few have been monitored despite ample evidence of unidentified organic fluorine in human and environmental samples. Nevertheless, our review of the literature indicates that nontarget analytical methods based on high-resolution mass spectrometry have been used to discover more than 750 PFASs, belonging to more than 130 diverse classes, in strategically selected environmental samples, biofluids or commercial products. Among these reports, we summarize the analytical and data-processing strategies for nontarget PFAS discovery, identify knowledge gaps and propose new areas for method development. Discovery of emerging PFASs before they are global contaminants could mitigate future contamination if strategic techniques can be developed to prioritize some of these substances for synthesis and confirmation, further monitoring, source elucidation and hazard characterization. (c) 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Department环境化学与生态毒理学国家重点实验室
KeywordHigh-resolution mass spectrometry (HRMS) Poly-/per-fluoroalkyl substances (PFASs) Nontarget discovery PFAS-Feature identification Suspect screening
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/42548
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Univ Alberta, Dept Lab Med & Pathol, Div Analyt & Environm Tox, Edmonton, AB T6G 2G3, Canada
3.D'Agostino, Lisa A.; Martin, Jonathan W.] Stockholm Univ, Dept Environm Sci & Analyt Chem, Sci Life Lab, S-10691 Stockholm, Sweden
4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yanna,D'Agostino, Lisa A.,Qu, Guangbo,et al. High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,121:-.
APA Liu, Yanna,D'Agostino, Lisa A.,Qu, Guangbo,Jiang, Guibin,&Martin, Jonathan W..(2019).High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,121,-.
MLA Liu, Yanna,et al."High-resolution mass spectrometry (HRMS) methods for nontarget discovery and characterization of poly- and per-fluoroalkyl substances (PFASs) in environmental and human samples".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 121(2019):-.
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