RCEES OpenIR  > 环境化学与生态毒理学国家重点实验室
Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure
Yin, Junfa1; Zhang, Ning; Wang, Hailin1
2019-11-01
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume120Pages:-
AbstractLong-term exposures to environmental toxicants are causative factors for human health effects. DNA damages are of great interest in that they can serve as the potential biomarkers of environmental exposure and mutations. Qualitative and quantitative detection of their level in genomic DNA, are helpful for the understanding of the generation, transformation, repair and fate of DNA damages and for elucidating the mechanism underlying carcinogenesis. Methodologies based on liquid chromatography-mass spectrometry (LC-MS) have shown unique advantages in accurate and highly sensitive analysis of these structurally modified DNA damages. The present review summarizes our current knowledge on LC-MS analysis of genetic DNA damages, with special emphasis on structurally chemical DNA modifications induced by environmental exposure. Advances in LC-MS analysis and monitoring of oxidative DNA lesion, DNA adducts induced by heavy metals, persistent organic pollutants, bisphenols, fine particulate matters, aldehydes and halobenzoquinones are comprehensively summarized. (c) 2019 Elsevier B.V. All rights reserved.
Department环境化学与生态毒理学国家重点实验室
KeywordDNA damage DNA modification Liquid chromatography-mass spectrometry Environmental exposure Environmental health
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/42556
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yin, Junfa,Zhang, Ning,Wang, Hailin. Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,120:-.
APA Yin, Junfa,Zhang, Ning,&Wang, Hailin.(2019).Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,120,-.
MLA Yin, Junfa,et al."Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 120(2019):-.
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