| Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure | |
Yin, Junfa1 ; Zhang, Ning; Wang, Hailin1
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| 2019-11-01 | |
| Source Publication | TRAC-TRENDS IN ANALYTICAL CHEMISTRY
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| ISSN | 0165-9936 |
| Volume | 120Pages:- |
| Abstract | Long-term exposures to environmental toxicants are causative factors for human health effects. DNA damages are of great interest in that they can serve as the potential biomarkers of environmental exposure and mutations. Qualitative and quantitative detection of their level in genomic DNA, are helpful for the understanding of the generation, transformation, repair and fate of DNA damages and for elucidating the mechanism underlying carcinogenesis. Methodologies based on liquid chromatography-mass spectrometry (LC-MS) have shown unique advantages in accurate and highly sensitive analysis of these structurally modified DNA damages. The present review summarizes our current knowledge on LC-MS analysis of genetic DNA damages, with special emphasis on structurally chemical DNA modifications induced by environmental exposure. Advances in LC-MS analysis and monitoring of oxidative DNA lesion, DNA adducts induced by heavy metals, persistent organic pollutants, bisphenols, fine particulate matters, aldehydes and halobenzoquinones are comprehensively summarized. (c) 2019 Elsevier B.V. All rights reserved. |
| Department | 环境化学与生态毒理学国家重点实验室 |
| Keyword | DNA damage DNA modification Liquid chromatography-mass spectrometry Environmental exposure Environmental health |
| Document Type | 期刊论文 |
| Identifier | http://ir.rcees.ac.cn/handle/311016/42556 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Yin, Junfa,Zhang, Ning,Wang, Hailin. Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,120:-. |
| APA | Yin, Junfa,Zhang, Ning,&Wang, Hailin.(2019).Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,120,-. |
| MLA | Yin, Junfa,et al."Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 120(2019):-. |
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| Liquid chromatograph（1454KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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