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Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China
Lu, Yao1; Gao, Ke1; Li, Xiaona2; Tang, Zhi3; Xiang, Li2; Zhao, Hongzhi2; Fu, Jianjie1; Wang, Ling4; Zhu, Nali5; Cai, Zongwei2; Liang, Yong4; Wang, Yawei1,4; Jiang, Guibin1
2019-08-20
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume53Issue:16Pages:9800-9809
AbstractOccupational workers are usually exposed to high levels of per- and polyfluoroalkyl substances (PFASs), placing them under greater health risks compared to the general population. Herein, 40 occupational workers from a factory in China and 52 control subjects from the general population were involved in an investigation on the potential health concerns of occupational exposure to PFASs by mass spectrometry-based metabolomics analysis. The PFAS levels in plasma from both groups were analyzed. Six PFAS congeners (Sigma(6)PFASs) were found to be the main components of the 13 detected PFASs, with a geometric mean of 1770 and 22.2 ng mL(-1) in occupational workers and the general population, respectively. Metabolic profiles of the plasma samples were acquired using liquid chromatography coupled with orbitrap high-resolution mass spectrometry and gas chromatography mass spectrometry. The partial least-squares-discriminant analysis model indicated that the plasma metabolic profiles of the two groups could be clearly separated. Differential and correlation analyses were applied to discover potential biomarkers. A total of 14 potential biomarkers were identified, and they were found to be associated with oxidative stress, fatty acid beta-oxidation disorder, and kidney injury. The obtained results indicated that the health effects of occupational exposure to PFASs on workers should not be ignored.
Department环境化学与生态毒理学国家重点实验室
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/42560
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
3.Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China
4.Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China
5.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China
6.Chinese Acad Sci, Inst Biophys, Lab Prote, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Lu, Yao,Gao, Ke,Li, Xiaona,et al. Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2019,53(16):9800-9809.
APA Lu, Yao.,Gao, Ke.,Li, Xiaona.,Tang, Zhi.,Xiang, Li.,...&Jiang, Guibin.(2019).Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China.ENVIRONMENTAL SCIENCE & TECHNOLOGY,53(16),9800-9809.
MLA Lu, Yao,et al."Mass Spectrometry-Based Metabolomics Reveals Occupational Exposure to Per- and Polyfluoroalkyl Substances Relates to Oxidative Stress, Fatty Acid beta-Oxidation Disorder, and Kidney Injury in a Manufactory in China".ENVIRONMENTAL SCIENCE & TECHNOLOGY 53.16(2019):9800-9809.
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