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RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay
Yang, Ying; Wang, Lu1,10,11,12; Han, Xiao; Yang, Wen-Lan; Zhang, Mengmeng5; Ma, Hai-Li; Sun, Bao-Fa; Li, Ang; Xia, Jun1; Chen, Jing; Heng, Jian1; Wu, Baixing5; Chen, Yu-Sheng; Xu, Jia-Wei; Yang, Xin; Yao, Huan; Sun, Jiawei7; Lyu, Cong; Wang, Hai-Lin; Huang, Ying9; Sun, Ying-Pu; Zhao, Yong-Liang; Meng, Anming7; Ma, Jinbiao5; Liu, Feng1; Yang, Yun-Gui
2019-09-19
Source PublicationMOLECULAR CELL
ISSN1097-2765
Volume75Issue:6Pages:1188-+
AbstractThe maternal-to-zygotic transition (MZT) is a conserved and fundamental process during which the maternal environment is converted to an environment of embryonic-driven development through dramatic reprogramming. However, how maternally supplied transcripts are dynamically regulated during MZT remains largely unknown. Herein, through genome-wide profiling of RNA 5-methylcytosine (m(5)C) modification in zebrafish early embryos, we found that m(5)C-modified maternal mRNAs display higher stability than non-m(5)C-modified mRNAs during MZT. We discovered that Y-box binding protein 1 (Ybx1) preferentially recognizes m(5)C--modified mRNAs through pi-pi interactions with a key residue, Trp45, in Ybx1's cold shock domain (CSD), which plays essential roles in maternal mRNA stability and early embryogenesis of zebrafish. Together with the mRNA stabilizer Pabpc1a, Ybx1 promotes the stability of its target mRNAs in an m(5)C-dependent manner. Our study demonstrates an unexpected mechanism of RNA m(5)C-regulated maternal mRNA stabilization during zebrafish MZT, highlighting the critical role of m(5)C mRNA modification in early development.
Department环境化学与生态毒理学国家重点实验室
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/42582
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Chinese Acad Sci, Coll Future Technol, Collaborat Innovat Ctr Genet & Dev, CAS Key Lab Genom & Precis Med,Beijing Inst Genom, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Univ Chinese Acad Sci, Sino Danish Coll, Beijing 101408, Peoples R China
5.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
6.Fudan Univ, Multiscale Res Inst Complex Syst, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn,Dept Biochem,Sch Life Sc, Shanghai 200438, Peoples R China
7.Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Reprod & Genet, Ctr Reprod Med, Zhengzhou 450052, Henan, Peoples R China
8.Tsinghua Univ, Lab Mol Dev Biol, State Key Lab Membrane Biol, Tsinghua Peking Ctr Life Sci,Sch Life Sci, Beijing 100084, Peoples R China
9.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China
10.Univ Chinese Acad Sci, State Key Lab Mol Biol, Shanghai Key Lab Mol Androl, Shanghai Inst Biochem & Cell Biol,Chinese Acad Sc, Shanghai 201204, Peoples R China
11.Chinese Acad Med Sci, State Key Lab Expt Hematol, Inst Hematol, Tianjin 300020, Peoples R China
12.Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China
13.Peking Union Med Coll, Tianjin 300020, Peoples R China
Recommended Citation
GB/T 7714
Yang, Ying,Wang, Lu,Han, Xiao,et al. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay[J]. MOLECULAR CELL,2019,75(6):1188-+.
APA Yang, Ying.,Wang, Lu.,Han, Xiao.,Yang, Wen-Lan.,Zhang, Mengmeng.,...&Yang, Yun-Gui.(2019).RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay.MOLECULAR CELL,75(6),1188-+.
MLA Yang, Ying,et al."RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay".MOLECULAR CELL 75.6(2019):1188-+.
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