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Role of protein corona in the biological effect of nanomaterials: Investigating methods
Zeng, Li1; Gao, Jiejun1; Liu, Yanna1; Gao, Jie1; Yao, Linlin1; Yang, Xiaoxi1; Liu, Xiaolei1; He, Bin1,2; Hu, Ligang1,2; Shi, Jianbo1,2; Song, Maoyong1,2; Qu, Guangbo1,2; Jiang, Guibin1,2
2019-09-01
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume118Pages:303-314
AbstractGrowing developments in engineered nanomaterials (NMs) and their wide applications inevitably raise environmental and human health concerns. Upon contact with biological fluids, NMs can attract proteins onto their surfaces to form dynamic layers called protein corona. Such new biological identities are what the bio-systems see and react with. Formation of protein corona around NMs determines the biological behavior of NMs and the transformation patterns of proteins. Therefore, characterization of the protein corona on NMs' surface is the first step towards understanding the nature of NMs-mediated biological effects. In this review, the roles of protein corona in NMs' bio-application and biosafety were summarized, with an emphasis on methods for characterizing NMs-protein interactions and the dynamic biological identities. Moreover, we extrapolated the discussion to environmentally relevant nanoparticles (e.g. PM 2.5) and macromolecules, and discussed the possible methods and challenges for studying their interactions with proteins. (C) 2019 Elsevier B.V. All rights reserved.
Department环境化学与生态毒理学国家重点实验室
KeywordProtein corona Engineered nanomaterial Method Nano-safety Environmentally relevant nanoparticle
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/42583
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
3.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Li,Gao, Jiejun,Liu, Yanna,et al. Role of protein corona in the biological effect of nanomaterials: Investigating methods[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,118:303-314.
APA Zeng, Li.,Gao, Jiejun.,Liu, Yanna.,Gao, Jie.,Yao, Linlin.,...&Jiang, Guibin.(2019).Role of protein corona in the biological effect of nanomaterials: Investigating methods.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,118,303-314.
MLA Zeng, Li,et al."Role of protein corona in the biological effect of nanomaterials: Investigating methods".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 118(2019):303-314.
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