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A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals
Li, Xueyan; Li, Aijing; Zhang, Wenjuan; Liu, Xiaowei; Liang, Yong; Yao, Xinglei; Song, Maoyong
2019-12-30
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
Volume186Pages:-
AbstractIt has been demonstrated that heavy metals cross the placental barrier and exert potentially harmful fetal effects. Although previous studies showed sex differences in response to similar intrauterine environments, little is known about fetal sex-related differences in placental transfer and accumulation of heavy metals. This study aimed to reveal the sex-specific risk of fetal exposure to heavy metals in pregnant women. We detected the exposure levels of eight heavy metals in 64 paired mother-infant maternal blood, cord blood and placental tissue samples. We found that the placental transfer efficiency (PTE) of titanium (Ti) and silver (Ag) was significantly higher in the group with male fetuses than that with female fetuses. The group with male fetuses had a larger placental:maternal blood ratio of Ag levels than the group with female fetuses, indicating fetal sex-related differences in placental transfer and accumulation of Ag. Prospective research should focus on the sex differences of adverse health effects induced by heavy metals and other pollutants.
Department环境纳米技术与健康效应重点实验室
KeywordHeavy metals Prenatal exposure Sex difference Placental transfer efficiency Placental accumulation Silver
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/43177
Collection环境纳米技术与健康效应重点实验室
Affiliation1.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Obstet, Beijing 100026, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China
3.Jianghan Univ, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Li, Xueyan,Li, Aijing,Zhang, Wenjuan,et al. A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,186:-.
APA Li, Xueyan.,Li, Aijing.,Zhang, Wenjuan.,Liu, Xiaowei.,Liang, Yong.,...&Song, Maoyong.(2019).A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,186,-.
MLA Li, Xueyan,et al."A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 186(2019):-.
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