| A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals | |
Li, Xueyan; Li, Aijing ; Zhang, Wenjuan; Liu, Xiaowei; Liang, Yong; Yao, Xinglei; Song, Maoyong
| |
| 2019-12-30 | |
| Source Publication | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| ISSN | 0147-6513 |
| Volume | 186Pages:- |
| Abstract | It has been demonstrated that heavy metals cross the placental barrier and exert potentially harmful fetal effects. Although previous studies showed sex differences in response to similar intrauterine environments, little is known about fetal sex-related differences in placental transfer and accumulation of heavy metals. This study aimed to reveal the sex-specific risk of fetal exposure to heavy metals in pregnant women. We detected the exposure levels of eight heavy metals in 64 paired mother-infant maternal blood, cord blood and placental tissue samples. We found that the placental transfer efficiency (PTE) of titanium (Ti) and silver (Ag) was significantly higher in the group with male fetuses than that with female fetuses. The group with male fetuses had a larger placental:maternal blood ratio of Ag levels than the group with female fetuses, indicating fetal sex-related differences in placental transfer and accumulation of Ag. Prospective research should focus on the sex differences of adverse health effects induced by heavy metals and other pollutants. |
| Department | 环境纳米技术与健康效应重点实验室 |
| Keyword | Heavy metals Prenatal exposure Sex difference Placental transfer efficiency Placental accumulation Silver |
| Document Type | 期刊论文 |
| Identifier | http://ir.rcees.ac.cn/handle/311016/43177 |
| Collection | 环境纳米技术与健康效应重点实验室 |
| Affiliation | 1.Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Obstet, Beijing 100026, Peoples R China 2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China 3.Jianghan Univ, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Xueyan,Li, Aijing,Zhang, Wenjuan,et al. A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,186:-. |
| APA | Li, Xueyan.,Li, Aijing.,Zhang, Wenjuan.,Liu, Xiaowei.,Liang, Yong.,...&Song, Maoyong.(2019).A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,186,-. |
| MLA | Li, Xueyan,et al."A pilot study of mothers and infants reveals fetal sex differences in the placental transfer efficiency of heavy metals".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 186(2019):-. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| A pilot study of mot（404KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment