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An overview of omics approaches to characterize the effect of perfluoroalkyl substances in environmental health
Yao, Xinglei; Cao, Dong; Wang, Fengbang; Zhang, Wenjuan; Ma, Chunyan; Song, Maoyong
2019-12-01
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume121Pages:-
AbstractThe production and widespread use of perfluoroalkyl substances (PFASs) has led to their presence in the environment, wildlife, and the human body. PFAS exposure has been indicated that could adversely affect human health. PFASs trigger chemical signals to cells, which further emit new signals to tissues and even to organs, and finally cause diseases. Detection of these signals and understanding of the meaning behind them are great challenges, which may be tackled through high-throughput 'omics' technologies, including transcriptomics, epigenomics, proteomics, and metabolomics. This review summarizes the analytical methodologies, such as sequencing, microarray, mass spectrometry (MS), and nuclear magnetic resonance (NMR), used in these 'omics' technologies and therefore applied in the bioanalysis of PFAS-related health risks. We provide a summary of the important roles that analytic methodologies have played in the study of human health. We also focus on new analytical technologies that will certainly shed light on new health-related fields. (c) 2018 Elsevier B.V. All rights reserved.
Department环境纳米技术与健康效应重点实验室
KeywordPerfluoroalkyl substances (PFASs) Perfluorooctanoate (PFOA) Perfluorooctane sulfonate (PFOS) Transcriptomics Epigenomics Proteomics Metabolomics RNA-Sequencing (RNA-seq) Mass spectrometer (MS) Nuclear magnetic resonance (NMR)
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/43179
Collection环境纳米技术与健康效应重点实验室
Affiliation1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Stake Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
2.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yao, Xinglei,Cao, Dong,Wang, Fengbang,et al. An overview of omics approaches to characterize the effect of perfluoroalkyl substances in environmental health[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,121:-.
APA Yao, Xinglei,Cao, Dong,Wang, Fengbang,Zhang, Wenjuan,Ma, Chunyan,&Song, Maoyong.(2019).An overview of omics approaches to characterize the effect of perfluoroalkyl substances in environmental health.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,121,-.
MLA Yao, Xinglei,et al."An overview of omics approaches to characterize the effect of perfluoroalkyl substances in environmental health".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 121(2019):-.
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