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Length and diameter-dependent phagocytosis and cytotoxicity of long silver nanowires in macrophages
Wang, Fengbang; Wang, Yuanyuan; Yao, Xinglei; Ma, Chunyan; Yin, Yongguang; Song, Maoyong
2019-12-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume237Pages:-
AbstractLong silver nanowires (AgNWs, >5 mu m) have shown promising applications in next generation biomaterials. However, the toxicity of long AgNWs is not well characterized in terms of their size. In this study, five AgNWs types, including SAgNW30 (length: 5-10 mu m; diameter: 30 nm), MAgNW30 (length: 20-30 mu m; diameter: 30 nm), LAgNW30 (length: similar to 100 pm; diameter: 30 nm), LAgNW50 (length: similar to 100 gm; diameter: 50 nm), and LAgNW100 (length: similar to 100 gm; diameter: 100 nm), were used to investigate the size-dependent phagocytosis and cytotoxicity in macrophage. It showed that SAgNW30, MAgNW30, LAgNW30 can be fully phagocytosed by macrophages, but LAgNW50 and LAgNW100 frustrated the phagocytosis. It demonstrated that LAgNW30 can be internalized into macrophage in a curly manner. The size-dependent cytotoxicity was observed in cell viability, apoptosis, mitochondrial damage, phenotypic transition, and inflammatory response in AgNWs-treated macrophage. The AgNWs-induced cytotoxicity was depended on their length and diameter, increased gradually in the order of SAgNW30 > MAgNW30 > LAgNW30 > LAgNW50 > LAgNW100. The findings presented here will assist in the evaluation of the size-dependent cytotoxicity mediated by long AgNWs. (C) 2019 Elsevier Ltd. All rights reserved.
Department环境纳米技术与健康效应重点实验室
KeywordLong AgNWs Macrophage Phagocytosis Cytotoxicity Size-dependent
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/43199
Collection环境纳米技术与健康效应重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Nanotechnol & Hlth Effects, Beijing 100085, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Fengbang,Wang, Yuanyuan,Yao, Xinglei,et al. Length and diameter-dependent phagocytosis and cytotoxicity of long silver nanowires in macrophages[J]. CHEMOSPHERE,2019,237:-.
APA Wang, Fengbang,Wang, Yuanyuan,Yao, Xinglei,Ma, Chunyan,Yin, Yongguang,&Song, Maoyong.(2019).Length and diameter-dependent phagocytosis and cytotoxicity of long silver nanowires in macrophages.CHEMOSPHERE,237,-.
MLA Wang, Fengbang,et al."Length and diameter-dependent phagocytosis and cytotoxicity of long silver nanowires in macrophages".CHEMOSPHERE 237(2019):-.
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