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Insight into the generation of toxic products during chloramination of carbamazepine: Kinetics, transformation pathway and toxicity
Han, Yingnan; Ma, Mei; Oda, Yoshimitsu; Rao, Kaifeng; Wang, Zijian; Yang, Rong; Liu, Yihong
2019-08-20
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume679Pages:221-228
AbstractAs a widely used andepileptic drug, carbamazepine (CBZ) has been frequently detected in aquatic environments, even in drinking water. Chloramine is a widely used alternative disinfectant due to its low-level formation of regulated disinfection byproducts (DBPs). However, there is previous evidence linking product mixtures of chloraminated CBZ to stronger DNA damage effects than those caused by CBZ itself. The present study further investigated the reaction rate, transformation mechanism and multi-endpoint toxicity of transformation products (TPs) of CBZ treated with NH2Cl under different pH conditions. The results showed that the reaction between CBZ and NH2Cl at pH 8.5, where NH2Cl is stable, is a second-order reaction with a rate of 4.2 M-1 h(-1). Compared to both alkaline and acidic conditions, CBZ was quickly degraded at pH 7. This indicated that HOCl produced from NH2Cl hydrolysis is more effective in degrading CBZ than NH2Cl and NHCl2. Furthermore, the concentration variation of four TPs formed during the chloramination of CBZ under different pH conditions was investigate by quantitative analysis, and the transformation pathway from CBZ to 9(10H)-acridone was confirmed. Three of the detected TPs showed cytotoxicity, DNA damage effects or chromosome damage effects. Acridine and 9(10H)-acridone, which accumulated with increasing time, showed higher cytotoxic or genotoxic effects than CBZ itself. In addition, a similar transformation mechanism was observed in real ambient water during simulated chloramination with a low level of CBZ. These results suggested that despite the chloramination of CBZ being slower than chlorination, TPs with higher cytotoxidty or genotoxidty may lead to greater toxic risks. (C) 2019 Elsevier B.V. All rights reserved.
Department中国科学院饮用水科学与技术重点实验室
KeywordCarbamazepine Chloramine Drinking water Genotoxicity Kinetics
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/43477
Collection中国科学院饮用水科学与技术重点实验室
Affiliation1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
3.Osaka Shin Ai Coll, Inst Life & Environm Sci, Tsurumi Ku, 6-2-28 Tsunani, Osaka 5380053, Japan
Recommended Citation
GB/T 7714
Han, Yingnan,Ma, Mei,Oda, Yoshimitsu,et al. Insight into the generation of toxic products during chloramination of carbamazepine: Kinetics, transformation pathway and toxicity[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,679:221-228.
APA Han, Yingnan.,Ma, Mei.,Oda, Yoshimitsu.,Rao, Kaifeng.,Wang, Zijian.,...&Liu, Yihong.(2019).Insight into the generation of toxic products during chloramination of carbamazepine: Kinetics, transformation pathway and toxicity.SCIENCE OF THE TOTAL ENVIRONMENT,679,221-228.
MLA Han, Yingnan,et al."Insight into the generation of toxic products during chloramination of carbamazepine: Kinetics, transformation pathway and toxicity".SCIENCE OF THE TOTAL ENVIRONMENT 679(2019):221-228.
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