Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri (2-butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP)

	Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri (2-butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP)
	Hou, Rui; Yuan, Shengwu ; Feng, Chenglian ; Xu, Yiping ; Rao, Kaifeng ; Wang, Zijian
	2019-06-10
Source Publication	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
Volume	668 Pages:806-814
Abstract	Alkylated organophosphate esters (alkyl-OPEs) are widely used and extensively detected in aquatic organisms. This work investigated the tissue-specific toxicokinetics of two common alkyl-OPEs, tri(2-butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP) in Chinese rare minnow (Gobiocypris rarus) through a 50 day uptake and depuration experiment. The tissue-specific bioconcentration factor (BCF) values for the two alkylOPEs ranged from 1 to 30 Likg wet weight (ww), with the kidney and ovary as the tissues with the highest accumulation. The tissue BCFs only exhibited a significant correlation with lipid contents only in storage tissues (i.e.. muscle, brain, ovary and testis), indicating that lipids might not be the major contributor to tissue distribution of TBOEP and TNBP. However, the contribution of blood perfusion and active transport to tissue-specific OPE accumulation needs to be further investigated. Lower accumulation of metabolites than parent chemicals was observed, with metabolite parent concentration factors (MPCFs) <1. Di-alkyl phosphate (DAP), bis(2-butoxyethyl) phosphate (BBOEP) and di(n-butyl) phosphate (DNBP) were the most abundantly formed metabolites of TBOEP and TNBP in various tissues, followed by the monohydroxylated OPEs (OH-OPEs). However, bis(2-butoxyethyl) hydroxyethyl phosphate (BBOEHEP), was detected at much lower levels in the tissues. All the investigated metabolites showed high production rates (k(prod,metabolites)) in the fish liver, followed by the GI tract and the kidney, indicating the importance of the hepatobiliaiy and urinary systems in eliminating the metabolites. Our study suggested that metabolism plays an important role in eliminating these two alkyl-OPEs in rare minnow and results in different tissue distribution mechanisms for metabolites and their compounds. (C) 2019 Elsevier B.V. All rights reserved.
Department	中国科学院饮用水科学与技术重点实验室
Keyword	Alkyl substituted organophosphate esters (alkyl-OPEs) Toxicokinetic Di-alkyl phosphate (DAP) Hydroxylated organophosphate ester Metabolite parent concentration factor
Document Type	期刊论文
Identifier	http://ir.rcees.ac.cn/handle/311016/43539
Collection	中国科学院饮用水科学与技术重点实验室
Affiliation	1.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China 2.Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China 3.Guangdong Univ Technol, Sch Environm Sci & Engn, Guangzhou 510006, Guangdong, Peoples R China 4.Chinese Res Inst Environm Sci, State Key Lab Environm Criteria & Risk Assessment, Beijing 100012, Peoples R China
Recommended Citation GB/T 7714	Hou, Rui,Yuan, Shengwu,Feng, Chenglian,et al. Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri (2-butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP)[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,668:806-814.
APA	Hou, Rui,Yuan, Shengwu,Feng, Chenglian,Xu, Yiping,Rao, Kaifeng,&Wang, Zijian.(2019).Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri (2-butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP).SCIENCE OF THE TOTAL ENVIRONMENT,668,806-814.
MLA	Hou, Rui,et al."Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri (2-butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP)".SCIENCE OF THE TOTAL ENVIRONMENT 668(2019):806-814.

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