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Application of electrophysiological technique in toxicological study: From manual to automated patch-clamp recording
Gao, Jia; Zhang, He; Xiong, Ping; Yan, Xueting; Liao, Chunyang; Jiang, Guibin
2020-12
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume133Pages:1-9
AbstractIon channels are common targets of a range of environmental substances, including pharmaceuticals, toxins, metals and many organic pollutants. Patch-clamp technique is gold standard in studying ion channel characteristics, contributing to the improved accuracy in active compound identification, the increasing studies of molecular mechanism behind diseases, and the better prediction of potential toxicants. Nevertheless, low throughput and high technical capability requirement limit the application of conventional manual patch-clamp recording and an emerging transformation towards automation and simplification is rising. The evolving automated patch-clamp technique shows obvious advances over manual technique in many aspects, including reproducibility, throughput, operability and standardization. The application of emerging automated patch-clamp platform has created valuable consequences in many research areas, especially in high throughput screening. In this study, we provided an overview on the progresses made by conventional manual and emerging automated patch-clamp techniques in toxicological studies. (C) 2020 Elsevier B.V. All rights reserved.
Department环境化学与生态毒理学国家重点实验室
KeywordManual patch-clamp Automated patch-clamp Ion channel characterization High throughput screening Toxicity
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/44607
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Gao, Jia,Zhang, He,Xiong, Ping,et al. Application of electrophysiological technique in toxicological study: From manual to automated patch-clamp recording[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2020,133:1-9.
APA Gao, Jia,Zhang, He,Xiong, Ping,Yan, Xueting,Liao, Chunyang,&Jiang, Guibin.(2020).Application of electrophysiological technique in toxicological study: From manual to automated patch-clamp recording.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,133,1-9.
MLA Gao, Jia,et al."Application of electrophysiological technique in toxicological study: From manual to automated patch-clamp recording".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 133(2020):1-9.
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