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Diverse and abundant antibiotic resistance genes in Chinese swine farms
Zhu, Yong-Guan; Johnson, Timothy A.; Su, Jian-Qiang; Qiao, Min; Guo, Guang-Xia; Stedtfeld, Robert D.; Hashsham, Syed A.; Tiedje, James M.; Zhu, YG
2013
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume110Issue:9Pages:3435-3440
AbstractAntibiotic resistance genes (ARGs) are emerging contaminants posing a potential worldwide human health risk. Intensive animal husbandry is believed to be a major contributor to the increased environmental burden of ARGs. Despite the volume of antibiotics used in China, little information is available regarding the corresponding ARGs associated with animal farms. We assessed type and concentrations of ARGs at three stages of manure processing to land disposal at three large-scale (10,000 animals per year) commercial swine farms in China. In-feed or therapeutic antibiotics used on these farms include all major classes of antibiotics except vancomycins. High-capacity quantitative PCR arrays detected 149 unique resistance genes among all of the farm samples, the top 63 ARGs being enriched 192-fold (median) up to 28,000-fold (maximum) compared with their respective antibiotic-free manure or soil controls. Antibiotics and heavy metals used as feed supplements were elevated in the manures, suggesting the potential for coselection of resistance traits. The potential for horizontal transfer of ARGs because of transposon-specific ARGs is implicated by the enrichment of transposases-the top six alleles being enriched 189-fold (median) up to 90,000-fold in manure-as well as the high correlation (r(2) = 0.96) between ARG and transposase abundance. In addition, abundance of ARGs correlated directly with antibiotic and metal concentrations, indicating their importance in selection of resistance genes. Diverse, abundant, and potentially mobile ARGs in farm samples suggest that unmonitored use of antibiotics and metals is causing the emergence and release of ARGs to the environment.
Department中澳联合土壤环境研究室
Indexed BySCI
WOS IDWOS:000315841900051
Citation statistics
Cited Times:653[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/7368
Collection土壤环境科学实验室
Corresponding AuthorZhu, YG
Recommended Citation
GB/T 7714
Zhu, Yong-Guan,Johnson, Timothy A.,Su, Jian-Qiang,et al. Diverse and abundant antibiotic resistance genes in Chinese swine farms[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(9):3435-3440.
APA Zhu, Yong-Guan.,Johnson, Timothy A..,Su, Jian-Qiang.,Qiao, Min.,Guo, Guang-Xia.,...&Zhu, YG.(2013).Diverse and abundant antibiotic resistance genes in Chinese swine farms.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,110(9),3435-3440.
MLA Zhu, Yong-Guan,et al."Diverse and abundant antibiotic resistance genes in Chinese swine farms".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110.9(2013):3435-3440.
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