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Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
Sheng, Ling-Hui; Chen, Hong-Rui; Huo, Ying-Bin; Wang, Jing; Zhang, Yu; Yang, Min; Zhang, Hong-Xun
2014
Source PublicationMOLECULES
ISSN1420-3049
Volume19Issue:1Pages:1212-1222
AbstractAntidepressants are a new kind of pollutants being increasingly found in wastewater. In this study, a fast and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry method was developed and validated for the analysis of 24 antidepressant drugs and six of their metabolites in wastewater. This is the first time that the antidepressant residues in wastewater of Beijing (China) were systematically reported. A solid-phase extraction process was performed with 3 M cation disk, followed by ultra-high performance liquid chromatography-tandem mass spectrometry measurements. The chromatographic separation and mass parameters were optimized in order to achieve suitable retention time and good resolution for analytes. All compounds were satisfactorily determined in one single injection within 20 min. The limit of quantification (LOQ), linearity, and extraction recovery were validated. The LOQ for analytes were ranged from 0.02 to 0.51 ng/mL. The determination coefficients were more than 0.99 within the tested concentration range (0.1-25 ng/mL), and the recovery rate for each target compound was ranged from 81.2% to 118% at 1 ng/mL. This new developed method was successfully applied to analysis the samples collected from Beijing municipal wastewater treatment plants. At least ten target antidepressants were found in all samples and the highest mean concentration of desmethylvenlafaxin was up to 415.6 ng/L.
Department中国科学院环境生物技术重点实验室
KeywordPharmaceuticals Antidepressants Drug Solid Phase Extraction Wastewater Treatment Plants
WOS IDWOS:000334420300076
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.rcees.ac.cn/handle/311016/9673
Collection中国科学院环境生物技术重点实验室
环境水质学国家重点实验室
Recommended Citation
GB/T 7714
Sheng, Ling-Hui,Chen, Hong-Rui,Huo, Ying-Bin,et al. Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. MOLECULES,2014,19(1):1212-1222.
APA Sheng, Ling-Hui.,Chen, Hong-Rui.,Huo, Ying-Bin.,Wang, Jing.,Zhang, Yu.,...&Zhang, Hong-Xun.(2014).Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry.MOLECULES,19(1),1212-1222.
MLA Sheng, Ling-Hui,et al."Simultaneous Determination of 24 Antidepressant Drugs and Their Metabolites in Wastewater by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry".MOLECULES 19.1(2014):1212-1222.
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