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人胚胎干细胞在药物毒性风险评估中的研究进展 期刊论文
现代药物与临床, 2019, 卷号: 34, 期号: 11, 页码: 3491-3496
Authors:  杨仁君;  梁小星;  郭恒;  王维娜;  沈素;  殷诺雅;  Francesco Faiola;  张杨
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人胚胎干细胞  细胞基础毒性  胚胎发育毒性  器官毒性  
Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 183, 页码: -
Authors:  Liang, Shaojun;  Liang, Shengxian;  Zhou, Hui;  Yin, Nuoya;  Faiola, Francesco
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Human neural stem cells (hNSCs)  TBBPA/TBBPS/TCBPA  BDE-209/BDE-47  Human neural developmental toxicity  GSK3 beta  T3 signaling  
Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 379, 页码: -
Authors:  Liang, Shengxian;  Liang, Shaojun;  Yin, Nuoya;  Hu, Bowen;  Faiola, Francesco
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BDE-47/209  TBBPA/S  TCBPA  Human embryonic stem cells  Developmental neural toxicity  
Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo 期刊论文
TOXICOLOGY LETTERS, 2019, 卷号: 312, 页码: 139-147
Authors:  Yang, Xiaoxi;  Ku, Tingting;  Sun, Zhendong;  Liu, Qian S.;  Yin, Nuoya;  Zhou, Qunfang;  Faiola, Francesco;  Liao, Chunyang;  Jiang, Guibin
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TCDD  Teratoma formation  Mouse embryonic stem cells  Teratocarcinoma  Carcinogenic effects  
New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells 期刊论文
ARCHIVES OF TOXICOLOGY, 2019, 卷号: 93, 期号: 9, 页码: 2661-2671
Authors:  Gu, Yu-Xin;  Liang, Xiao-Xing;  Yin, Nuo-Ya;  Yang, Yu;  Wan, Bin;  Guo, Liang-Hong;  Faiola, Francesco
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Bisphenol analogues  O-GlcNAcase  Inhibition  Neurotoxicity  
Genetic diversity of diazotrophs and total bacteria in the phyllosphere of Pyrus serotina, Prunus armeniaca, Prunus avium, and Vitis vinifera 期刊论文
CANADIAN JOURNAL OF MICROBIOLOGY, 2019, 卷号: 65, 期号: 9, 页码: 642-652
Authors:  Liang, Shengxian;  Liu, Hao;  Wu, Shanghua;  Xu, Shengjun;  Jin, Decai;  Faiola, Francesco;  Zhuang, Xuliang;  Zhuang, Guoqiang;  Qu, Dong;  Fan, Haiyan;  Bai, Zhihui
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phyllosphere  diazotroph diversity  nifH  16S rDNA  clone library  
Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity 期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2019, 卷号: 376, 页码: 223-232
Authors:  Liang, Shaojun;  Zhou, Hui;  Yin, Nuoya;  Lu, Yuanping;  Faiola, Francesco
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Mouse embryonic stem cells (mESCs)  Tetrabromobisphenol A (TBBPA)  Embryoid bodies (EBs)  Developmental toxicity  
Embryonic stem cell- and transcriptomics-based in vitro analyses reveal that bisphenols A, F and S have similar and very complex potential developmental toxicities 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 176, 页码: 330-338
Authors:  Yin, Nuoya;  Liang, Xiaoxing;  Liang, Shengxian;  Lan, Shaojun;  Yang, Renjun;  Hu, Bowen;  Cheng, Zhanwen;  Liu, Shuyu;  Dong, Hengzhi;  Liu, Sijin;  Faiola, Francesco
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Mouse embryonic stem cells (mESCs)  Bisphenols A, F and S  Developmental toxicity  Stem cell toxicology  
Establishment of a human embryonic stem cell-based liver differentiation model for hepatotoxicity evaluations 期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 174, 页码: 353-362
Authors:  Liang, Shengxian;  Liang, Shaojun;  Yin, Nuoya;  Faiola, Francesco
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Thyroid hormones (THs)  Polybrominated diphenyl ethers BDE-47/209  Human embryonic stem cells (ESCs)  Developmental hepatotoxicity  Endocrine-disrupting chemicals (EDCs)  
Human Pluripotent Stem Cells as Tools for Predicting Developmental Neural Toxicity of Chemicals: Strategies, Applications, and Challenges 期刊论文
STEM CELLS AND DEVELOPMENT, 2019, 卷号: 28, 期号: 12, 页码: 755-768
Authors:  Liang, Shengxian;  Yin, Nuoya;  Faiola, Francesco
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developmental neural toxicity (DNT)  human pluripotent stem cells (hPSCs)  neural differentiation  neurons  astrocytes  oligodendrocytes