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Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis
Fan, Rui-mei; Zhu, Ben-zhan; Huang, Chin-pao; Sheng, Zhi-guo; Mao, Li; Li, Ming-xin
2016-12
Source PublicationENVIRONMENTAL TOXICOLOGY
Volume31Issue:12Pages:1964-1973
AbstractBoth metam sodium and copper/zinc-containing compounds are widely used as fungicides. They therefore may co-occur in the biosphere. Despite certain studies of individual toxicity for either metam or copper (II)/zinc (II), their synergistic toxicity has not been examined. In this paper, a remarkable synergistic toxicity was observed in HepG2 cells when metam and copper (II)/zinc (II) at non-toxic and sub-toxic levels were combined. Unexpectedly, cell death modes between metam/copper (II) and metam/zinc (II) were different: For metam/copper (II), apoptosis was evident from morphological characteristics including cytoplasm-chromatin condensation, phosphatidylserine (PS) exposure, SubG(0)/G(1) DNA fragmentation, mitochondrial membrane potential decrease, pro/anti-apoptotic protein activation, and cytochrome c release; for metam/zinc (II), necrosis was evident from organelle swelling and uncontrolled collapse. To our knowledge, this work first not only demonstrates the synergistic toxicities of metam and both copper (II)/zinc (II), but also verifies the different modes of apoptosis/necrosis between metam/copper (II) and metam/zinc (II). (C) 2015 Wiley Periodicals, Inc.
Department环境化学与生态毒理学国家重点实验室
KeywordMetam Copper (Ii) Zinc (Ii) Synergistic Toxicity Apoptosis Necrosis
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Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/35839
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Fan, Rui-mei,Zhu, Ben-zhan,Huang, Chin-pao,et al. Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis[J]. ENVIRONMENTAL TOXICOLOGY,2016,31(12):1964-1973.
APA Fan, Rui-mei,Zhu, Ben-zhan,Huang, Chin-pao,Sheng, Zhi-guo,Mao, Li,&Li, Ming-xin.(2016).Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis.ENVIRONMENTAL TOXICOLOGY,31(12),1964-1973.
MLA Fan, Rui-mei,et al."Different Modes of Synergistic Toxicities between Metam/Copper (II) and Metam/Zinc (II) in HepG2 Cells: Apoptosis vs. Necrosis".ENVIRONMENTAL TOXICOLOGY 31.12(2016):1964-1973.
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