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Review of OPFRs in animals and humans: Absorption, bioaccumulation, metabolism, and internal exposure research
Hou, Rui; Xu, Yiping; Wang, Zijian
2016-06
Source PublicationCHEMOSPHERE
Volume153Issue:0Pages:78-90
AbstractDue to their widespread use, organophosphate flame retardants (OPFRs) are commonly detected in various environmental matrices and have been identified as emerging contaminants. Considering the adverse effects of OPFRs, many researchers have paid their attention on the absorption, bioaccumulation, metabolism and internal exposure processes of OPFRs in animals and humans. In this article, we first review the diverse absorption routes of OPFR5 by animals and humans (e.g., inhalation, ingestion, dermal absorption and gill absorption). Bioaccumulation and biomagnification potentials of OPFRs in different types of organisms and food webs are also summarized, based on quite limited available data and results. For metabolism, we review the Phase-I and Phase-II metabolic processes for each type of OPFR5 (chlorinated OPFRs, alkyl-OPFRs and aryl-OPFRs) in the animals and humans, as well as toxicokinetic information and putative exposure biomarkers on OPFRs. Finally, we highlight gaps in our knowledge and critical directions for future internal exposure studies of OPFRs in animals and humans. (C) 2016 Elsevier Ltd. All rights reserved.
Department中国科学院饮用水科学与技术重点实验室
KeywordOrganophosphorus Flame Retardants (Opfrs) Absorption Bioaccumulation Metabolism Internal Exposure
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Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/36209
Collection中国科学院饮用水科学与技术重点实验室
Recommended Citation
GB/T 7714
Hou, Rui,Xu, Yiping,Wang, Zijian. Review of OPFRs in animals and humans: Absorption, bioaccumulation, metabolism, and internal exposure research[J]. CHEMOSPHERE,2016,153(0):78-90.
APA Hou, Rui,Xu, Yiping,&Wang, Zijian.(2016).Review of OPFRs in animals and humans: Absorption, bioaccumulation, metabolism, and internal exposure research.CHEMOSPHERE,153(0),78-90.
MLA Hou, Rui,et al."Review of OPFRs in animals and humans: Absorption, bioaccumulation, metabolism, and internal exposure research".CHEMOSPHERE 153.0(2016):78-90.
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