RCEES OpenIR  > 环境化学与生态毒理学国家重点实验室
Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae
Shi, Qipeng; Wang, Min; Shi, Fengqiong; Yang, Lihua; Guo, Yongyong; Feng, Chenglian; Liu, Jingfu; Zhou, Bingsheng
2018-10-01
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume203Pages:80-87
AbstractTriphenyl phosphate (TPhP), a typical organophosphate ester, is frequently detected in the environment and biota samples. It has been implicated as a neurotoxin as its structure is similar to neurotoxic organophosphate pesticides. The purpose of the present study was to investigate its potential developmental neurotoxicity in fish by using zebrafish larvae as a model. Zebrafish (Danio rerio) embryos were exposed to 0.8, 4, 20 and 100 mu g/L of TPhP from 2 until 144 h post-fertilization. TPhP was found to have high bioconcentrations in zebrafish larvae after exposure. Further, it significantly reduced locomotor activity as well as the heart rate at the 100 mu g/L concentration. TPhP exposure significantly altered the content of the neurotransmitters gamma-aminobutyric and histamine. Downregulation of the genes related to central nervous system development (e.g., al-tubulin, mbp, syn2a, shha, and elavl3) as well as the corresponding proteins (e.g., al-tubulin, mbp, and syn2a) was observed, but the gap-43 protein was found to upregulated. Finally, marked inhibition of total acetylcholinesterase activity, which is considered as a biomarker of neurotoxicant exposure, was also observed in the larvae. Our results indicate that exposure to environmentally relevant concentrations of TPhP can affect different parameters related to center nervous system development, and thus contribute to developmental neurotoxicity in early developing zebrafish larvae.
Department环境化学与生态毒理学国家重点实验室
KeywordTriphenyl phosphate Bioconcentration Developmental neurotoxicity Environmental risk Zebrafish embryos/larvae
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/40918
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Shi, Qipeng,Wang, Min,Shi, Fengqiong,et al. Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae[J]. AQUATIC TOXICOLOGY,2018,203:80-87.
APA Shi, Qipeng.,Wang, Min.,Shi, Fengqiong.,Yang, Lihua.,Guo, Yongyong.,...&Zhou, Bingsheng.(2018).Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae.AQUATIC TOXICOLOGY,203,80-87.
MLA Shi, Qipeng,et al."Developmental neurotoxicity of triphenyl phosphate in zebrafish larvae".AQUATIC TOXICOLOGY 203(2018):80-87.
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