| Role of protein corona in the biological effect of nanomaterials: Investigating methods | |
Zeng, Li1; Gao, Jiejun1; Liu, Yanna1; Gao, Jie1; Yao, Linlin1; Yang, Xiaoxi1; Liu, Xiaolei1; He, Bin1,2; Hu, Ligang1,2; Shi, Jianbo1,2; Song, Maoyong1,2 ; Qu, Guangbo1,2; Jiang, Guibin1,2
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| 2019-09-01 | |
| Source Publication | TRAC-TRENDS IN ANALYTICAL CHEMISTRY
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| ISSN | 0165-9936 |
| Volume | 118Pages:303-314 |
| Abstract | Growing developments in engineered nanomaterials (NMs) and their wide applications inevitably raise environmental and human health concerns. Upon contact with biological fluids, NMs can attract proteins onto their surfaces to form dynamic layers called protein corona. Such new biological identities are what the bio-systems see and react with. Formation of protein corona around NMs determines the biological behavior of NMs and the transformation patterns of proteins. Therefore, characterization of the protein corona on NMs' surface is the first step towards understanding the nature of NMs-mediated biological effects. In this review, the roles of protein corona in NMs' bio-application and biosafety were summarized, with an emphasis on methods for characterizing NMs-protein interactions and the dynamic biological identities. Moreover, we extrapolated the discussion to environmentally relevant nanoparticles (e.g. PM 2.5) and macromolecules, and discussed the possible methods and challenges for studying their interactions with proteins. (C) 2019 Elsevier B.V. All rights reserved. |
| Department | 环境化学与生态毒理学国家重点实验室 |
| Keyword | Protein corona Engineered nanomaterial Method Nano-safety Environmentally relevant nanoparticle |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/42583 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 3.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | Zeng, Li,Gao, Jiejun,Liu, Yanna,et al. Role of protein corona in the biological effect of nanomaterials: Investigating methods[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,118:303-314. |
| APA | Zeng, Li.,Gao, Jiejun.,Liu, Yanna.,Gao, Jie.,Yao, Linlin.,...&Jiang, Guibin.(2019).Role of protein corona in the biological effect of nanomaterials: Investigating methods.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,118,303-314. |
| MLA | Zeng, Li,et al."Role of protein corona in the biological effect of nanomaterials: Investigating methods".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 118(2019):303-314. |
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| Role of protein coro（902KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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