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Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion
Lu, Dawei; Luo, Qian; Chen, Rui; Zhuansun, Yongxun; Jiang, Jie; Wang, Weichao; Yang, Xuezhi; Zhang, Luyao; Liu, Xiaolei; Li, Fang; Liu, Qian; Jiang, Guibin
2020-05-22
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume11Issue:1Pages:1-11
AbstractAmbient particulate matter pollution is one of the leading causes of global disease burden. Epidemiological studies have revealed the connections between particulate exposure and cardiovascular and respiratory diseases. However, until now, the real species of ambient ultrafine particles (UFPs) in humans are still scarcely known. Here we report the discovery and characterization of exogenous nanoparticles (NPs) in human serum and pleural effusion (PE) samples collected from non-occupational subjects in a typical polluted region. We show the wide presence of NPs in human serum and PE samples with extreme diversity in chemical species, concentration, and morphology. Through chemical multi-fingerprinting (including elemental fingerprints, high-resolution structural fingerprints, and stable iron isotopic fingerprints) of NPs, we identify the sources of the NPs to be abiogenic, particularly, combustion-derived particulate emission. Our results provide evidence for the translocation of ambient UFPs into the human circulatory system, and also provide information for understanding their systemic health effects. Exposure to ambient particulate matter is one of the leading global health risks. Here, the authors reveal, by means of chemical multi-fingerprinting, the presence of exogenous ultrafine particles with diverse species and morphology in non-occupational human serum and pleural effusion.
Department环境化学与生态毒理学国家重点实验室
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/44630
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Lu, Dawei,Luo, Qian,Chen, Rui,et al. Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion[J]. NATURE COMMUNICATIONS,2020,11(1):1-11.
APA Lu, Dawei.,Luo, Qian.,Chen, Rui.,Zhuansun, Yongxun.,Jiang, Jie.,...&Jiang, Guibin.(2020).Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion.NATURE COMMUNICATIONS,11(1),1-11.
MLA Lu, Dawei,et al."Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion".NATURE COMMUNICATIONS 11.1(2020):1-11.
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