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Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis
Chen, Weifang; Yu, Miao; Zhang, Qing; Hou, Xingwang; Kong, Wenqian; Wei, Linfeng; Mao, Xiaowei; Liu, Jiyan; Schnoor, Jerald L.; Jiang, Guibin
2020-08-18
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume54Issue:16Pages:9990-9999
AbstractShort-chain and medium-chain chlorinated paraffins (SCCPs and MCCPs) are mixtures of complex chemical compounds with intensive usage. They are frequently detected in various environmental samples. However, the interaction between CPs and plants, especially the biotransformation behaviors of CPs within plants, is poorly understood. In this study, 1,2,5,6,9,10-hexachlorodecane (CP-4, a typical standard of individual SCCP congeners) and 52%-MCCP (a commercial mixture standard of MCCPs with 52% chlorine content by mass) were selected as representative chemicals to explore the metabolic behaviors of SCCPs and MCCPs using suspension rice cell culture exposure systems. Both 79.53% and 40.70% of CP-4 and 52%-MCCP were metabolized by suspension rice cells, respectively. A complementary suspected screening strategy based on the pair mass distances (PMD) analysis algorithm was used to study the metabolism of CPs mediated by the plant cells. Forty and 25 metabolic products for CP-4 and 52%-MCCP, respectively, were identified, including (multi-) hydroxylation, dechlorination, -HCI- elimination metabolites, (hydroxylation-) sulfation, and glycosylation conjugates. Here, we propose a comprehensive metabolic molecular network and provide insight on degradation pathways of SCCPs and MCCPs in plants for the first time, aiding in further understanding of the transformation behaviors of CPs.
Department环境化学与生态毒理学国家重点实验室
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/44733
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Chen, Weifang,Yu, Miao,Zhang, Qing,et al. Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2020,54(16):9990-9999.
APA Chen, Weifang.,Yu, Miao.,Zhang, Qing.,Hou, Xingwang.,Kong, Wenqian.,...&Jiang, Guibin.(2020).Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis.ENVIRONMENTAL SCIENCE & TECHNOLOGY,54(16),9990-9999.
MLA Chen, Weifang,et al."Metabolism of SCCPs and MCCPs in Suspension Rice Cells Based on Paired Mass Distance (PMD) Analysis".ENVIRONMENTAL SCIENCE & TECHNOLOGY 54.16(2020):9990-9999.
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