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The biodistribution and transformation of nanoparticulate and ionic silver in rat organs in vivo
Dong, Lijie; Lai, Yujian; Zhou, Hongyu; Yan, Bing; Liu, Jingfu
2020-10
Source PublicationNANOIMPACT
ISSN2452-0748
Volume20Pages:1-10
AbstractDetermination of the biodistribution, transformation of nanoparticulate and ionic silver species is of significant importance for insight understanding mechanism behinds the toxicity of silver nanoparticles (AgNPs), which are widely used in numerous sectors. Their highly dynamic properties may lead to coexposure to nanoparticulate and ionic silver. Herein, an accurate speciation analysis of the biodistribution and transformation of the individual and co-administered particulate and ionic Ag in rat organs in vivo was performed by using a versatile analytical method developed for the separation, quantification and size characterization of different silver species in multiple rat organs (liver, spleen, heart, brain, lung and kidney), with mass detection limits of 0.1-0.2 mu g/g for AgNPs and Ag(I), and size characterization precision of 0.2%-1.6% for AgNPs. Then, after intravenous (i.v.) exposure to either Ag+, AgNPs, or a mixture of Ag+ and AgNPs, the distribution of different silver species in rat organs was quantitatively determined. We found that most of the accumulated silver existed in complexed Ag(I) form in all organs, only a small fraction of AgNPs was detected in liver and lung, and the AgNPs taken up in organs were either rapidly and completely dissolved or maintained in their original core size in 3 days after exposure. More importantly, while there was a negligible combined effect on the uptake or redistribution of different silver species, the coexistence of Ag+ could accelerate the dissolution of administered AgNPs by the remarkable overexpression of metallothioneins.
Department环境化学与生态毒理学国家重点实验室
KeywordSilver species Combined effects Rat organs Biodistribution Transformation
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/44821
Collection环境化学与生态毒理学国家重点实验室
Recommended Citation
GB/T 7714
Dong, Lijie,Lai, Yujian,Zhou, Hongyu,et al. The biodistribution and transformation of nanoparticulate and ionic silver in rat organs in vivo[J]. NANOIMPACT,2020,20:1-10.
APA Dong, Lijie,Lai, Yujian,Zhou, Hongyu,Yan, Bing,&Liu, Jingfu.(2020).The biodistribution and transformation of nanoparticulate and ionic silver in rat organs in vivo.NANOIMPACT,20,1-10.
MLA Dong, Lijie,et al."The biodistribution and transformation of nanoparticulate and ionic silver in rat organs in vivo".NANOIMPACT 20(2020):1-10.
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