| Environmental relevant concentration of lambda-cyhalothrin and 3-phenoxybenzoic acid caused endocrine-disrupting effects on male lizards (Eremias argus) | |
Chang, Jing; Pan, Yifan; Yang, Lu; Xie, Yun; Xu, Peng; Wang, Huili
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| 2020-10 | |
| Source Publication | ENVIRONMENTAL POLLUTION
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| ISSN | 0269-7491 |
| Volume | 265Pages:1-10 |
| Abstract | In the present study, the endocrine toxicity of LCT and PBA was investigated through exposure to Eremias argus for two weeks under environmental relevant concentration. RNA-sequencing identified 4442 and 4653 differentially expressed genes in lizard liver after LCT and PBA exposure. Four differentially expressed genes (hsd17 beta, ar, sult, ugt) related with hypothalamic-pituitary-gonadal axis were quantified by qPCR. The expression of genes associated with HPG axis in different tissues differed significantly. In LCT treatment group, ar, cyp17 and hsd3 beta genes involved in testosterone synthesis and transportation were significantly decreased in lizard testes, and the spermatogensis was inhibited in the testes, which indicated the anti-androgenic activity of LCT. After PBA exposure, the genes related with estradiol synthesis, transportation and metabolism, such as hsd17 beta, er alpha, ugt in lizard liver were important biomarkers and the significant decrease of estradiol level was highly correlated with hsd17 beta, er alpha, ugt gene expressions. The relative high binding affinity of PBA with ER alpha further demonstrated the anti-estrogenic activity of PBA. Our results elucidate the different toxic mechanism of LCT and PBA on lizard endocrine system at environmental relevant concentration. Pyrethroids metabolism may cause more seriously toxicity rather than detoxification. (C) 2020 Elsevier Ltd. All rights reserved. |
| Department | 中国科学院环境生物技术重点实验室 |
| Keyword | Pyrethroids Reptiles Metabolite Hypothalamic-pituitary-gonad (HPG) Gonadal disruption |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/45165 |
| Collection | 中国科学院环境生物技术重点实验室 |
| Recommended Citation GB/T 7714 | Chang, Jing,Pan, Yifan,Yang, Lu,et al. Environmental relevant concentration of lambda-cyhalothrin and 3-phenoxybenzoic acid caused endocrine-disrupting effects on male lizards (Eremias argus)[J]. ENVIRONMENTAL POLLUTION,2020,265:1-10. |
| APA | Chang, Jing,Pan, Yifan,Yang, Lu,Xie, Yun,Xu, Peng,&Wang, Huili.(2020).Environmental relevant concentration of lambda-cyhalothrin and 3-phenoxybenzoic acid caused endocrine-disrupting effects on male lizards (Eremias argus).ENVIRONMENTAL POLLUTION,265,1-10. |
| MLA | Chang, Jing,et al."Environmental relevant concentration of lambda-cyhalothrin and 3-phenoxybenzoic acid caused endocrine-disrupting effects on male lizards (Eremias argus)".ENVIRONMENTAL POLLUTION 265(2020):1-10. |
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| Environmental releva（3003KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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