| A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation | |
Liu, Yiyun; Chen, Yangsheng; Sha, Rui; Li, Yunping; Xu, Tong ; Hu, Xiaoxu; Xu, Li; Xie, Qunhui; Zhao, Bin
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| 2021-09 | |
| Source Publication | ENVIRONMENT INTERNATIONAL
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| ISSN | 0160-4120 |
| Volume | 154Pages:- |
| Abstract | Cancer occurrence and development are closely related to the environment. Aryl hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many environmental compounds, and is also involved in regulating tumor cell migration. Glioblastoma is the most malignant glioma and exhibits high motility, but the effects of AhR on the migration of glioblastoma are still unclear. We aimed to understand the role of AhR in the migration of this type of tumor cell and to explore the underlying molecular mechanism. In cultured human neuroblastoma cells (U87), we found that AhR overexpression or knockdown increased or suppressed the migration ability of U87 cells, respectively. Furthermore, inhibition of basal activation of the AhR pathway suppressed migration ability, suggesting a positive correlation between endogenous activity of the AhR pathway and cell migration. When the AhR pathway was activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 6formyl [3,2-b] carbazole (FICZ), the migration of U87 cells was inhibited by inducing the expression of a tumor suppressor, IL24, which is a downstream responsive gene of AhR activation. Moreover, a similar AhR-IL24dependent mechanism for migration inhibition of TCDD was documented in a breast cancer cell line and a lung cancer cell line. This study demonstrated that AhR plays important roles in regulating the migration of glioblastoma, and the induction of the AhR-IL24 axis mediates the inhibition of migration in response to TCDD or FICZ treatment. |
| Department | 环境化学与生态毒理学国家重点实验室 |
| Keyword | Glioblastoma Aryl hydrocarbon receptor Interleukin 24 Migration |
| WOS Research Area | Environmental Sciences |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/45640 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Yiyun,Chen, Yangsheng,Sha, Rui,et al. A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation[J]. ENVIRONMENT INTERNATIONAL,2021,154:-. |
| APA | Liu, Yiyun.,Chen, Yangsheng.,Sha, Rui.,Li, Yunping.,Xu, Tong.,...&Zhao, Bin.(2021).A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation.ENVIRONMENT INTERNATIONAL,154,-. |
| MLA | Liu, Yiyun,et al."A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation".ENVIRONMENT INTERNATIONAL 154(2021):-. |
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