Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure

	Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure
	Gao, Jie ; Wang, Shunhao ; Tang, Gang ; Wang, Ziniu ; Ma, Junjie ; Wang, Yuanyuan ; Liu, Yaquan ; Guo, Hao ; Li, Junya ; Lv, Meilin ; Li, Danyang ; Hu, Ligang ; Shi, Jianbo ; He, Bin ; Qu, Guangbo ; Jiang, Guibin
	2021-08
Source Publication	MATERIALS & DESIGN
ISSN	0264-1275
Volume	206 Pages:-
Abstract	In this study, we comprehensively explored graphene oxide (GO)-induced systemic immune responses and interference with hematopoiesis in mice upon GO intravenous injection. In the liver and spleen, GO led to alterations in immune components at different time points. GO exposure showed an effect on the populations of different types of hepatic macrophages. In the liver, the populations of macrophages mainly affected by GO including Kupffer cells and monocyte-derived macrophages. Stimulated hepatic inflammation led to the infiltration of platelets from the circulation into the liver and decreased peripheral platelets population at day 1. Interestingly, a decreased platelet population was observed on day 7 in the spleen. GO also led to accelerated hematopoiesis in the spleen. Therefore, the possible forced generation of more platelets and the release of mature platelets from the spleen contributed to the increased circulating platelet count on day 7. Therefore, although GO showed a low potential to induce severe inflammation in the liver and spleen, it disrupted hematopoiesis in the spleen, which contributed to fluctuations in circulating platelet counts. The interaction of GO with the immune system warrants comprehensive study for gaining better understanding.& nbsp; (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Department	环境化学与生态毒理学国家重点实验室
Keyword	Graphene oxide In vivo Alterations of platelets Disturbance of splenic hematopoiesis
WOS Research Area	Materials Science, Multidisciplinary
Document Type	期刊论文
Identifier	https://ir.rcees.ac.cn/handle/311016/45654
Collection	环境化学与生态毒理学国家重点实验室
Affiliation	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Northeastern Univ, Coll Sci, Res Ctr Analyt Sci, Dept Chem, Shenyang 110819, Peoples R China
Recommended Citation GB/T 7714	Gao, Jie,Wang, Shunhao,Tang, Gang,et al. Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure[J]. MATERIALS & DESIGN,2021,206:-.
APA	Gao, Jie.,Wang, Shunhao.,Tang, Gang.,Wang, Ziniu.,Ma, Junjie.,...&Jiang, Guibin.(2021).Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure.MATERIALS & DESIGN,206,-.
MLA	Gao, Jie,et al."Altered immune cells in the liver and spleen of mice as a typical immune response to graphene oxide exposure".MATERIALS & DESIGN 206(2021):-.

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