| Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence | |
Deng, Shenxi; Yan, Xueting; Xiong, Ping; Li, Guoliang; Ku, Tingting; Liu, Na; Liao, Chunyang; Jiang, Guibin
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| 2021-06-01 | |
| Source Publication | SCIENCE OF THE TOTAL ENVIRONMENT
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| ISSN | 0048-9697 |
| Volume | 771Pages:- |
| Abstract | Metal-organic frameworks (MOFs) exhibit broad potential applications in the environmental, biomedical, catalyst, and energy fields. However, the currently existing data hardly shed light on their health risks before the MOFs' large-scale usage. In this context, we exploratively investigated the in vivo fate and effect of one representative cobalt-based zeolitic imidazolate framework (ZIF-67) at the nano- (60 nm) and submicron- (890 nm) scales. Different from submicron-scale ZIF-67 showing better biosafety, nanoscale particles manifested a neuro-degenerative risk at the dose of no general toxicity, evidenced by the impairment of learning and memory ability and disordered function of the neuropeptide signaling pathway in a rat model. The involvement of oxidative damage and inflammatory processes in the neurotoxicity induced by ZIF-67 was discussed as well. These findings not only provide a wake-up call for the prudent applications of MOFs but also provide insight into the better design and safer use of MOFs for broader applications. (C) 2021 Elsevier B.V. All rights reserved. |
| Department | 环境化学与生态毒理学国家重点实验室 |
| Keyword | Metal-organic frameworks (MOFs) Neurotoxicity Learning and memory Transcriptomic analysis Biosafety assessment |
| WOS Research Area | Environmental Sciences |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/45789 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Deng, Shenxi,Yan, Xueting,Xiong, Ping,et al. Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,771:-. |
| APA | Deng, Shenxi.,Yan, Xueting.,Xiong, Ping.,Li, Guoliang.,Ku, Tingting.,...&Jiang, Guibin.(2021).Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence.SCIENCE OF THE TOTAL ENVIRONMENT,771,-. |
| MLA | Deng, Shenxi,et al."Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence".SCIENCE OF THE TOTAL ENVIRONMENT 771(2021):-. |
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| Nanoscale cobalt-bas（2925KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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