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Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence
Deng, Shenxi; Yan, Xueting; Xiong, Ping; Li, Guoliang; Ku, Tingting; Liu, Na; Liao, Chunyang; Jiang, Guibin
2021-06-01
Source PublicationSCIENCE OF THE TOTAL ENVIRONMENT
ISSN0048-9697
Volume771Pages:-
AbstractMetal-organic frameworks (MOFs) exhibit broad potential applications in the environmental, biomedical, catalyst, and energy fields. However, the currently existing data hardly shed light on their health risks before the MOFs' large-scale usage. In this context, we exploratively investigated the in vivo fate and effect of one representative cobalt-based zeolitic imidazolate framework (ZIF-67) at the nano- (60 nm) and submicron- (890 nm) scales. Different from submicron-scale ZIF-67 showing better biosafety, nanoscale particles manifested a neuro-degenerative risk at the dose of no general toxicity, evidenced by the impairment of learning and memory ability and disordered function of the neuropeptide signaling pathway in a rat model. The involvement of oxidative damage and inflammatory processes in the neurotoxicity induced by ZIF-67 was discussed as well. These findings not only provide a wake-up call for the prudent applications of MOFs but also provide insight into the better design and safer use of MOFs for broader applications. (C) 2021 Elsevier B.V. All rights reserved.
Department环境化学与生态毒理学国家重点实验室
KeywordMetal-organic frameworks (MOFs) Neurotoxicity Learning and memory Transcriptomic analysis Biosafety assessment
WOS Research AreaEnvironmental Sciences
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/45789
Collection环境化学与生态毒理学国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Deng, Shenxi,Yan, Xueting,Xiong, Ping,et al. Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,771:-.
APA Deng, Shenxi.,Yan, Xueting.,Xiong, Ping.,Li, Guoliang.,Ku, Tingting.,...&Jiang, Guibin.(2021).Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence.SCIENCE OF THE TOTAL ENVIRONMENT,771,-.
MLA Deng, Shenxi,et al."Nanoscale cobalt-based metal-organic framework impairs learning and memory abilitywithout noticeable general toxicity: First in vivo evidence".SCIENCE OF THE TOTAL ENVIRONMENT 771(2021):-.
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