| Toxicity of Tetrabromobisphenol A and Its Derivative in the Mouse Liver Following Oral Exposure at Environmentally Relevant Levels | |
Yao, Linlin; Wang, Yuanyuan; Shi, Jianbo; Liu, Yanna; Guo, Hao; Yang, Xiaoxi; Liu, Yaquan; Ma, Junjie; Li, Danyang; Wang, Ziniu; Li, Zikang; Luo, Qian; Fu, Jianjie ; Zhang, Qinghua; Qu, Guangbo; Wang, Yanxin; Jiang, Guibin
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| 2021-06-15 | |
| Source Publication | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| ISSN | 0013-936X |
| Volume | 55Issue:12Pages:8191-8202 |
| Abstract | As typical brominated flame retardants (BFRs), tetrabromobisphenol A (TBBPA) and its derivative TBBPA-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE) are ubiquitous in various environmental compartments. However, the potential health risk posed by these compounds, especially at environmentally relevant levels, remains unclear. In this study, using adult male mice, we investigated the toxicity of orally administered TBBPA and TBBPA-BDBPE at an environmentally relevant dose (57 nmol/kg body weight). After a single exposure and daily exposure, we assessed lipid metabolism homeostasis, the transcriptome, and immune cell components in the liver. We found that the single exposure to TBBPA or TBBPA-BDBPE alone increased the number of hepatic macrophages, induced alterations in the levels of lipids, including triacylglycerol and free fatty acids, and caused transcriptome perturbation. The results from the daily administration groups showed that TBBPA and TBBPA-BDBPE both significantly increased the triacylglycerol content; however, the elevation of hepatic macrophages was observed only in the TBBPA-BDBPE treatment group. This study confirmed that environmentally relevant levels of TBBPA and TBBPA-BDBPE are toxic to the liver. Our findings revealed that dysfunction of the liver is a health concern, following exposure to BFRs, even at very low concentrations. The chronic effects induced by TBBPA and its derivatives should be further investigated. |
| Department | 环境化学与生态毒理学国家重点实验室 |
| Keyword | brominated flame retardants mouse liver multiomics immunity |
| WOS Research Area | Engineering, Environmental ; Environmental Sciences |
| Document Type | 期刊论文 |
| Identifier | https://ir.rcees.ac.cn/handle/311016/45864 |
| Collection | 环境化学与生态毒理学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Sch Environm, Hangzhou Inst Adv Study, Hangzhou 310000, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Peoples R China 5.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China 6.China Univ Geosci, Sch Environm Studies, Wuhan 430074, Peoples R China |
| Recommended Citation GB/T 7714 | Yao, Linlin,Wang, Yuanyuan,Shi, Jianbo,et al. Toxicity of Tetrabromobisphenol A and Its Derivative in the Mouse Liver Following Oral Exposure at Environmentally Relevant Levels[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2021,55(12):8191-8202. |
| APA | Yao, Linlin.,Wang, Yuanyuan.,Shi, Jianbo.,Liu, Yanna.,Guo, Hao.,...&Jiang, Guibin.(2021).Toxicity of Tetrabromobisphenol A and Its Derivative in the Mouse Liver Following Oral Exposure at Environmentally Relevant Levels.ENVIRONMENTAL SCIENCE & TECHNOLOGY,55(12),8191-8202. |
| MLA | Yao, Linlin,et al."Toxicity of Tetrabromobisphenol A and Its Derivative in the Mouse Liver Following Oral Exposure at Environmentally Relevant Levels".ENVIRONMENTAL SCIENCE & TECHNOLOGY 55.12(2021):8191-8202. |
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| Toxicity of Tetrabro（3087KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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