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Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka
Cooray, Titus; Zhang, Junya; Zhong, Hui; Zheng, Libing; Wei, Yuansong; Weragoda, Sujithra K.; Jinadasa, K. B. S. N.; Weerasooriya, Rohan
2021-02-05
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
Volume403Pages:-
AbstractThe chronic kidney disease of unknown etiology (CKDu) prevalent in certain regions of Sri Lanka poses a serious threat to human health. Previous epidemiological studies focused on the search of causative agents for CKDu etiology from the viewpoint of groundwater composition, but how CKDu prevalence affected the groundwater microbial composition, especially the antibiotic resistome, has never been illuminated. This study investigated the response of microbial community and antibiotic resistome to CKDu prevalence in the groundwater through the high throughput sequencing and qPCR (HT-qPCR), respectively. Results showed that CKDu prevalence significantly influenced the distribution of antibiotic resistome and microbial community composition. The mexF dominated in all the groundwater samples and could be considered as an intrinsic ARG, and the beta-lactamase cphA was specially enriched and closely associated with the antibiotics used for CKDu patients. The Acinetobacter was a potential human pathogen common in the groundwater of CKDu affected regions, while CKDu prevalence specially enriched the Aeromonas. Statistical analysis indicated that CKDu prevalence impacted antibiotic resistome through the microbial community as a whole, and MGEs contributed to the occurrence of mexF, while the enrichment of cphA could be attributed to the increase of Aeromonas.
Department水污染控制实验室
KeywordChronic kidney disease of unknown etiology Groundwater Antibiotic resistome Microbial community Sri Lanka
WOS Research AreaEngineering, Environmental ; Environmental Sciences
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46063
Collection水污染控制实验室
Affiliation1.Chinese Acad Sci, State Key Joint Lab Environm Simulat & Pollut Con, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Dept Water Pollut Control Technol, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Uva Wellassa Univ, Dept Appl Earth Sci, Badulla 90000, Sri Lanka
5.Natl Water Supply & Drainage Board, Katugastota 20800, Sri Lanka
6.Univ Peradeniya, Fac Engn, Dept Civil Engn, Peradeniya 20400, Sri Lanka
Recommended Citation
GB/T 7714
Cooray, Titus,Zhang, Junya,Zhong, Hui,et al. Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,403:-.
APA Cooray, Titus.,Zhang, Junya.,Zhong, Hui.,Zheng, Libing.,Wei, Yuansong.,...&Weerasooriya, Rohan.(2021).Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka.JOURNAL OF HAZARDOUS MATERIALS,403,-.
MLA Cooray, Titus,et al."Profiles of antibiotic resistome and microbial community in groundwater of CKDu prevalence zones in Sri Lanka".JOURNAL OF HAZARDOUS MATERIALS 403(2021):-.
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