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Effect of gut microbiota on in vitro bioaccessibility of heavy metals and human health risk assessment from ingestion of contaminated soils*
Yin, Naiyi; Zhao, Yongli; Wang, Pengfei; Du, Huili; Yang, Mei; Han, Zeliang; Chen, Xiaochen; Sun, Guoxin; Cui, Yanshan
2021-06-15
Source PublicationENVIRONMENTAL POLLUTION
ISSN0269-7491
Volume279Pages:-
AbstractTo identify the role of gut microbiota in human health risk assessment, the bioaccessibility of heavy metals in 14 soil samples were determined in simulated gastrointestinal fluids. Compared to the small intestinal phase, the bioaccessibility values of the colon phase varied, either increased by 3.5-fold for As, by 2.2-fold for Cr, and by 1.6-fold for Ni, or reduced by 4.4-fold for Cu, respectively. The colon incubation with adult gut microbiota yielded higher bioaccessibility value of As (1.3 times) and Fe (3.4 times) than that of the child in most soil samples. Colon bioaccessibility was about 60% greater of Cd for the adult and 30% higher of Cr for the child. Congruent data on the bioaccessibility of Cu and Ni was observed. In addition, correlation analysis indicated that in vitro bioaccessibility was primarily related to total concentrations of heavy metals in soils, followed by soil pH and active Fe/Mn oxide. Significantly, risk assessment calculated based on colon bioaccessibility indicated that the target hazard quotient (THQ> 1) of As was presented in 3 soil samples for the adult (1.05-3.35) and in 9 soil samples for the child (1.06-26.93). The hazard index (HI) of the child was 4.00 on average, greater than that of the adult (0.62), primarily due to the contribution of As and Cd. It suggested non-carcinogenic risks are likely to occur in children through typical hand-to-mouth behavior. The adjustment of colon bioaccessibility will result in more accurate risk assessment of human exposure to heavy metals from oral ingestion of contaminated soils. (c) 2021 Elsevier Ltd. All rights reserved.
Department土壤环境科学与技术实验室
KeywordSoil Heavy metal Bioaccessibility Gut microbiota Health risk
WOS Research AreaEnvironmental Sciences
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46090
Collection土壤环境科学实验室
Affiliation1.Univ Chinese Acad Sci, Coll Resources & Environm, 380 Huaibeizhuang, Beijing 101408, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China
3.Fuzhou Univ, Coll Environm & Resources, Fujian Prov Engn Res Ctr Rural Waste Recycling Te, Fuzhou 350108, Peoples R China
Recommended Citation
GB/T 7714
Yin, Naiyi,Zhao, Yongli,Wang, Pengfei,et al. Effect of gut microbiota on in vitro bioaccessibility of heavy metals and human health risk assessment from ingestion of contaminated soils*[J]. ENVIRONMENTAL POLLUTION,2021,279:-.
APA Yin, Naiyi.,Zhao, Yongli.,Wang, Pengfei.,Du, Huili.,Yang, Mei.,...&Cui, Yanshan.(2021).Effect of gut microbiota on in vitro bioaccessibility of heavy metals and human health risk assessment from ingestion of contaminated soils*.ENVIRONMENTAL POLLUTION,279,-.
MLA Yin, Naiyi,et al."Effect of gut microbiota on in vitro bioaccessibility of heavy metals and human health risk assessment from ingestion of contaminated soils*".ENVIRONMENTAL POLLUTION 279(2021):-.
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