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Significant increase in extreme heat events along an urban-rural gradient
Cao, Jie; Zhou, Weiqi; Wang, Jing; Hu, Xiaofang; Yu, Wenjuan; Zheng, Zhong; Wang, Weimin
2021
Source PublicationLANDSCAPE AND URBAN PLANNING
ISSN0160-4120
Volume157Pages:-
AbstractPer- and poly-fluorinated substances (PFASs) with endocrine disrupting effect can efficiently transfer across the blood-follicle barrier. However, it is still controversial and attracting extensive public concern that whether PFASs can affect the human fertility potential. Therefore, we aimed to analyze the associations of women's exposure to PFASs with pregnancy loss, the relevant processes of fertilization, zygote implantation, and embryo development by using a prospective cohort study. The women undergoing in vitro fertilization-embryo transfer (IVF-ET) treatment were recruited in Beijing City (Beijing Center) and Yantai City (Yantai Center) in China during 2015-2017. A total of 305 women were recruited before the IVF-ET treatment. Twelve PFASs were measured in their serum samples collected in the day before the IVF-ET treatment, as well as in the human chorionic gonadotropin (hCG) day. The three IVF-ET outcomes were included, i.e. hCG test negative, clinical pregnancy failure (CPF), and preclinical spontaneous abortion. Nine serum PFASs had detection rate of >70% in Beijing and Yantai centers. The exposure patterns to PFASs between these two centers were overall different. For Beijing Center, we only found a positive association of perflurodecanoic acid (PFDA) with the risk of CPF [RR = 2.28 (95 %CI: 1.02-5.11)], but there is a reverse trend in Yantai Center with [RR = 0.45 (95 %CI: 0.23-0.85)]. However, the serum concentration of PFDA in Beijing Center was relatively lower than that of Yantai Center. Other significant associations of the detected PFASs with the IVF-ET outcomes, or with the relevant clinical processes, were not found. The multi-pollutant regression model of the Bayesian kernel machine regression suggested that there were no joint effects between various PFASs on the concerned outcomes. Overall, we suggest that most PFAS were not associated with early pregnancy loss at the current exposure levels. As for the PFDA, there may exist susceptibility of different populations.
Department城市与区域生态国家重点实验室
KeywordPer-and poly-fluorinated compounds PFASs Pregnancy loss In vitro fertilization-embryo transfer Risk
Document Type期刊论文
Identifierhttps://ir.rcees.ac.cn/handle/311016/46757
Collection城市与区域生态国家重点实验室
Affiliation1.Univ Sci & Technol China, Sch Life Sci, Div Life Sci & Med, Hefei 230027, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Shuangqing Rd, Beijing 100085, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing Urban Ecosyst Res Stn, Beijing 100085, Peoples R China
5.Minist Agr & Rural Affairs, Rural Energy & Environm Agcy, Beijing 100125, Peoples R China
6.[Wang, Weimin
7.Shenzhen Environm Monitoring Ctr, Shenzhen 518000, Peoples R China
Recommended Citation
GB/T 7714
Cao, Jie,Zhou, Weiqi,Wang, Jing,et al. Significant increase in extreme heat events along an urban-rural gradient[J]. LANDSCAPE AND URBAN PLANNING,2021,157:-.
APA Cao, Jie.,Zhou, Weiqi.,Wang, Jing.,Hu, Xiaofang.,Yu, Wenjuan.,...&Wang, Weimin.(2021).Significant increase in extreme heat events along an urban-rural gradient.LANDSCAPE AND URBAN PLANNING,157,-.
MLA Cao, Jie,et al."Significant increase in extreme heat events along an urban-rural gradient".LANDSCAPE AND URBAN PLANNING 157(2021):-.
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